Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.41 |
| ▸ | MMP1 | P03956 | 7/20 | 0.41 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671394 | 0.74 | MMP1 (0.45) | MMP9MMP1MMP3MMP2MMP7 | |
| SCHEMBL7350978 | 0.68 | KCNA5 (0.54) | MMP9MMP1MMP3MMP2MMP13 | |
| SCHEMBL8477947 | 0.67 | KCNA5 (0.45) | MMP9MMP1MMP2MMP13KCNA5 | |
| SCHEMBL7419400 | 0.67 | KCNA5 (0.48) | MMP9MMP1MMP3MMP2MMP7 | |
| SCHEMBL11453114 | 0.66 | ALDH1A1 (0.56) | SMN1; SMN2CA1CA2ACHECYP1A2 | |
| SCHEMBL7351711 | 0.65 | KCNA5 (0.53) | MMP9MMP1MMP2MMP13KCNA5 | |
| SCHEMBL209395 | 0.65 | KMT2A (0.59) | HTTSMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8675938 | 0.64 | KEAP1 (0.46) | MMP9MMP1MMP3MMP2MMP7 | |
| SCHEMBL7421563 | 0.64 | KEAP1 (0.48) | MMP9MMP1MMP2MMP13KCNA5 | |
| SCHEMBL26381709 | 0.64 | PKM (0.53) | MMP9MMP1MMP3MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770624-A | INHIBITORS OF TUMOR NECROSIS FACTOR ALPHA AND MATRIX DEGRADING METALLOPROTEINEASE ACTIVITY | NOVARTIS CORP. (US) | 1998-06-23 | — | — | US | disclosed |