Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7208697 | 0.68 | ADRA2C (0.35) | HTR2AGPR3CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL7201366 | 0.66 | GPR3 (0.45) | HTR2ACYP19A1GPR3ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8854555 | 0.64 | HTR2A (0.36) | HTR2AMTNR1AMTNR1BGPR3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9412844 | 0.63 | HTR2A (0.34) | HTR2ACYP19A1ALDH1A1MAPTMEN1 | |
| SCHEMBL9449351 | 0.62 | HRH3 (0.51) | HTR2AGPR3ALDH1A1MAPTMEN1 | |
| SCHEMBL30818407 | 0.62 | GPR3 (0.46) | HTR2ACYP19A1GPR3ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7201110 | 0.61 | CYP1A2 (0.46) | HTR2ACYP19A1GPR3ALDH1A1MAPT | |
| SCHEMBL7941153 | 0.60 | GPR3 (0.44) | HTR2ACYP19A1GPR3ALDH1A1MAPT | |
| SCHEMBL6828591 | 0.60 | HPGD (0.65) | ALDH1A1MAPTKMT2AHPGDMAOB | |
| SCHEMBL21625552 | 0.59 | CYP1A2 (0.50) | HTR2AACHEALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710222-A | CATALYTIC POLYMERIZATION OF PROPYLENE WITH METALLOCENE COMPOUND WITH GROUP IVB METAL AND EXTRATION | FINA TECHNOLOGY, INC. (US) | 1998-01-20 | — | — | US | claimed |