SCHEMBL8675983

SCHEMBL8675983

Cn1nc(Cl)n(-c2ccc(Br)cc2CCl)c1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SETDB1 Q15047 1/20 0.38
CASP2 P42575 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HPGD P15428 2/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
BRD9 Q9H8M2 2/20 0.33
PKM P14618 1/20 0.32
ALDH1A1 P00352 2/20 0.32
HIF1A Q16665 1/20 0.32
ACHE P22303 1/20 0.31
HTT P42858 1/20 0.31
BRD7 Q9NPI1 1/20 0.30
PTGER1 P34995 2/20 0.30
ALDH2 P05091 1/20 0.30
ALDH3A1 P30838 1/20 0.30
CUL4A Q13619 1/20 0.30
MYC P01106 1/20 0.30
NR4A1 P22736 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8660658 0.86 SETDB1 (0.39) SETDB1SMN1; SMN2LMNATSHRBRD9
SCHEMBL8664609 0.84 SETDB1 (0.37) SETDB1SMN1; SMN2LMNABRD9BRD7
SCHEMBL8664656 0.81 SETDB1 (0.40) SETDB1CASP2SMN1; SMN2ALDH1A1HTT
SCHEMBL8155272 0.80 NPC1 (0.34) SETDB1SMN1; SMN2LMNAL3MBTL1BRD9
SCHEMBL23712860 0.78 P2RX7 (0.35) CASP2SMN1; SMN2BRD9MYCNR4A1
SCHEMBL31728570 0.72 GSK3A (0.49) SMN1; SMN2HPGDTSHRL3MBTL1BRD9
SCHEMBL8670561 0.68 DDR1 (0.35) SETDB1SMN1; SMN2LMNATSHRBRD9
SCHEMBL8499784 0.68 ALDH1A1 (0.36) LMNATSHRBRD9ALDH1A1HTT
SCHEMBL8663188 0.67 ALDH1A1 (0.42) SETDB1SMN1; SMN2LMNABRD9ALDH1A1
SCHEMBL8590523 0.64 KDM4E (0.47) HPGDLMNAL3MBTL1ALDH1A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874831-A1 PROCESSES AND COMPOUNDS FOR PREPARING CYCLIC UREA FUNGICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-11-04 EP disclosed
WO-1997019935-A1 PROCESSES AND COMPOUNDS FOR PREPARING CYCLIC UREA FUNGICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-06-05 WO disclosed