Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324677 | 0.86 | L3MBTL1 (0.64) | L3MBTL1ALDH1A1MAPK1PTGER1PTGER4 | |
| SCHEMBL27838097 | 0.83 | TBXAS1 (0.58) | L3MBTL1TBXAS1TDP1 | |
| SCHEMBL9003138 | 0.83 | HRH1 (0.61) | L3MBTL1ALDH1A1MAPK1HRH1DRD2 | |
| SCHEMBL6761026 | 0.82 | DRD2 (0.62) | L3MBTL1ALDH1A1MAPK1TBXAS1HRH1 | |
| SCHEMBL8015205 | 0.82 | L3MBTL1 (0.61) | L3MBTL1ALDH1A1MAPK1TBXAS1CFD | |
| SCHEMBL9271339 | 0.81 | CXCL8 (0.51) | L3MBTL1CFDPLGPLAUF11 | |
| SCHEMBL6697391 | 0.80 | PPARD (0.50) | L3MBTL1TBXAS1HRH1 | |
| SCHEMBL27838095 | 0.80 | TBXAS1 (0.57) | L3MBTL1TBXAS1KMT2ATDP1 | |
| SCHEMBL27838177 | 0.78 | TBXAS1 (0.56) | L3MBTL1TBXAS1SLC6A3KMT2ATDP1 | |
| SCHEMBL5661211 | 0.76 | TBXAS1 (0.53) | L3MBTL1ALDH1A1MAPK1PTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739351-A | NEUROKININ A ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1998-04-14 | — | — | US | disclosed |
| US-5508433-A | Derivatives of perhydroisoindole and preparation thereof | RHONE-POULENC RORER S.A. (FR) | 1996-04-16 | — | — | US | disclosed |
| US-5451601-A | Perhydroisoindole derivatives and pharmaceutical compositions containing them | RHONE-POULENC RORER S.A. (FR) | 1995-09-19 | — | — | US | disclosed |