Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6761026 | 0.84 | DRD2 (0.62) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL8682147 | 0.83 | L3MBTL1 (0.54) | HRH1DRD2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8998047 | 0.83 | HRH1 (0.64) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL8324677 | 0.82 | L3MBTL1 (0.64) | DRD2ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL4845984 | 0.82 | HRH1 (0.58) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL8015205 | 0.79 | L3MBTL1 (0.61) | ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL5577016 | 0.77 | ALDH1A1 (0.54) | ALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL11754849 | 0.77 | HRH1 (1.00) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL5661211 | 0.76 | TBXAS1 (0.53) | DRD2ALDH1A1MAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4310487 | 0.76 | LTA4H (0.53) | ALDH1A1MAPK1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508433-A | Derivatives of perhydroisoindole and preparation thereof | RHONE-POULENC RORER S.A. (FR) | 1996-04-16 | — | — | US | disclosed |
| US-5451601-A | Perhydroisoindole derivatives and pharmaceutical compositions containing them | RHONE-POULENC RORER S.A. (FR) | 1995-09-19 | — | — | US | disclosed |