Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722603 | 0.95 | STAT3 (0.50) | STAT3STAT1 | |
| SCHEMBL7877923 | 0.91 | STAT3 (0.42) | STAT3STAT1 | |
| SCHEMBL899159 | 0.86 | STAT3 (0.71) | STAT3STAT1 | |
| SCHEMBL224519 | 0.83 | STAT3 (0.48) | STAT3STAT1 | |
| SCHEMBL30426808 | 0.80 | STAT3 (0.56) | STAT3STAT1 | |
| SCHEMBL1978627 | 0.80 | STAT3 (0.56) | STAT3STAT1 | |
| SCHEMBL1290623 | 0.80 | STAT3 (0.56) | STAT3STAT1 | |
| SCHEMBL80002 | 0.79 | STAT3 (0.48) | STAT3STAT1 | |
| SCHEMBL9754334 | 0.79 | STAT3 (0.48) | STAT3STAT1 | |
| SCHEMBL869195 | 0.79 | STAT3 (0.48) | STAT3STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243294-A1 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | DUKE UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
| US-8759324-B2 | Method of activation of oxazaphosphorines | DUKE UNIVERSITY (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130172296-A1 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | UNIV DUKE (US) | 2013-07-04 | — | — | US | disclosed |
| US-8399434-B2 | Method of activation of oxazaphosphorines | DUKE UNIVERSITY (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120077782-A9 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | DUKE UNIVERSITY (US) | 2012-03-29 | — | — | US | disclosed |
| US-20090318388-A1 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | DUKE UNIVERSITY (US) | 2009-12-24 | — | — | US | disclosed |
| WO-2008073195-A2 | METHOD FOR ACTIVATION OF OXAZAPHOSPHORINES | DUKE UNIVERSITY (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318388-A1 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | PPOX, HMBS, OAT | STAT3 3574/4885STAT1 3297/4885 |
| US-20140243294-A1 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | PPOX, HMBS, OAT | STAT3 3574/4885STAT1 3297/4885 |
| US-20120077782-A9 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | PPOX, HMBS, OAT | STAT3 3574/4885STAT1 3297/4885 |
| US-20130172296-A1 | METHOD OF ACTIVATION OF OXAZAPHOSPHORINES | PPOX, HMBS, OAT | STAT3 3574/4885STAT1 3297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.