Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712827 | 0.88 | LTA4H (0.46) | LTA4HSLC6A1HRH1 | |
| SCHEMBL8685369 | 0.88 | LTA4H (0.46) | LTA4HSLC6A1ALDH1A1LMNATSHR | |
| SCHEMBL8716401 | 0.85 | LTA4H (0.46) | LTA4HSLC6A1KDM4EALDH1A1S1PR5 | |
| SCHEMBL8690225 | 0.84 | LTA4H (0.46) | LTA4HSLC6A1CHRM2CHRM1CHRM3 | |
| SCHEMBL8715983 | 0.80 | SLC6A1 (0.66) | SLC6A1 | |
| SCHEMBL8712871 | 0.76 | LTA4H (0.57) | LTA4HSLC6A1 | |
| SCHEMBL6628169 | 0.72 | CCR3 (0.59) | LTA4HHTR2A | |
| SCHEMBL6630519 | 0.72 | CCR3 (0.59) | LTA4HHTR2A | |
| SCHEMBL8635915 | 0.70 | LTA4H (0.83) | LTA4H | |
| SCHEMBL31202577 | 0.69 | CD69 (0.50) | LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721260-A | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACID OR ESTER; ANALGESICS, ANTIINFLAMMATORY AGENTS, CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-02-24 | — | — | US | claimed |
| EP-0825981-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-03-04 | — | — | EP | disclosed |
| US-5721260-A | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACID OR ESTER; ANALGESICS, ANTIINFLAMMATORY AGENTS, CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-02-24 | — | — | US | disclosed |
| WO-1996031468-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-10 | — | — | WO | disclosed |