Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 9/20 | 0.37 |
| ▸ | CNR2 | P34972 | 9/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14983792 | 0.90 | DGAT1 (0.36) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL867844 | 0.89 | FASN (0.38) | PTGS2CTSD | |
| SCHEMBL3026367 | 0.87 | PGR (0.39) | CNR1CNR2 | |
| SCHEMBL2036052 | 0.84 | CNR2 (0.38) | CNR2SLC6A3CTSD | |
| SCHEMBL868403 | 0.82 | MARS1 (0.36) | EDNRBEDNRACNR1CNR2PTGS2 | |
| SCHEMBL12632679 | 0.82 | FASN (0.35) | PTGS2CTSD | |
| SCHEMBL2037804 | 0.82 | F9 (0.36) | CTSD | |
| SCHEMBL1319794 | 0.80 | EDNRB (0.41) | EDNRBEDNRACNR1PTGS2SLC6A3 | |
| SCHEMBL10121157 | 0.79 | EDNRB (0.39) | EDNRBEDNRACNR1CNR2PTGS2 | |
| SCHEMBL29435275 | 0.79 | EDNRB (0.39) | EDNRBEDNRACNR1CNR2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160950-B1 | HERBICIDAL PROPYNYL-PHENYL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2020-05-13 | — | — | EP | disclosed |
| EP-3209133-B1 | HERBICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-10-03 | — | — | EP | disclosed |
| EP-3004063-B1 | HERBICIDALLY ACTIVE 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS AND DERIVATIVES THEREOF | SYNGENTA LTD (GB) | 2018-07-18 | — | — | EP | disclosed |
| EP-3004052-B1 | HERBICIDALLY ACTIVE (ALKYNYL-PHENYL)-SUBSTITUTED CYCLIC DIONE COMPOUNDS AND DERIVATIVES THEREOF | SYNGENTA LTD (GB) | 2018-04-18 | — | — | EP | disclosed |
| EP-3004043-B1 | HERBICIDALLY ACTIVE (ALKYNYL-PHENYL)-SUBSTITUTED CYCLIC DIONE COMPOUNDS AND DERIVATIVES THEREOF | SYNGENTA LTD (GB) | 2018-01-31 | — | — | EP | disclosed |
| EP-2935230-B1 | HERBICIDALLY ACTIVE CYCLIC DIONE COMPOUNDS, OR DERIVATIVES THEREOF, SUBSTITUTED BY A PHENYL WHICH HAS AN ALKYNYL-CONTAINING SUBSTITUENT | SYNGENTA LTD (GB) | 2018-01-17 | — | — | EP | disclosed |
| EP-3209657-A1 | HERBICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2017-08-30 | — | — | EP | disclosed |
| EP-2986593-B1 | HERBICIDALLY ACTIVE 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS AND DERIVATIVES THEREOF | SYNGENTA LTD (GB) | 2017-07-19 | — | — | EP | disclosed |
| US-8987476-B2 | Spiro epoxides as intermediates | SYNGENTA LIMITED (GB) | 2015-03-24 | — | — | US | disclosed |
| US-20140135508-A1 | SPIRO EPOXIDES AS INTERMEDIATES | SYNGENTA LIMITED (GB) | 2014-05-15 | — | — | US | disclosed |
| US-8680299-B2 | Spiro epoxides as intermediates | SYNGENTA LIMITED (GB) | 2014-03-25 | — | — | US | disclosed |
| US-20130137573-A1 | HERBICIDAL COMPOSITIONS COMPRISING, AND METHODS OF USE OF, HERBICIDALLY ACTIVE PYRANDIONES | SYNGENTA LIMITED (US) | 2013-05-30 | — | — | US | disclosed |
| US-20130137573-A1 | HERBICIDAL COMPOSITIONS COMPRISING, AND METHODS OF USE OF, HERBICIDALLY ACTIVE PYRANDIONES | SYNGENTA LIMITED (US) | 2013-05-30 | — | — | US | disclosed |
| US-20130137573-A1 | HERBICIDAL COMPOSITIONS COMPRISING, AND METHODS OF USE OF, HERBICIDALLY ACTIVE PYRANDIONES | SYNGENTA LIMITED (US) | 2013-05-30 | — | — | US | disclosed |
| WO-2012175899-A1 | HERBICIDAL COMPOSITION COMPRISING A PYRANDIONE HERBICIDE AND A SULFONYL UREA HERBICIDE | SYNGENTA LIMITED (GB) | 2012-12-27 | — | — | WO | disclosed |
| EP-2523555-A2 | HERBICIDAL COMPOSITIONS COMPRISING, AND METHODS OF USE OF, HERBICIDALLY ACTIVE PYRANDIONES | Syngenta Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| US-20120077993-A1 | SPIRO EPOXIDES AS INTERMEDIATES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-29 | — | — | US | disclosed |
| WO-2011073616-A2 | HERBICIDAL COMPOSITIONS COMPRISING, AND METHODS OF USE OF, HERBICIDALLY ACTIVE PYRANDIONES | SYNGENTA LIMITED (GB) | 2011-06-23 | — | — | WO | disclosed |
| WO-2010136431-A9 | SPIRO EPOXIDES AS INTERMEDIATES | SYNGENTA LIMITED (GB) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077993-A1 | SPIRO EPOXIDES AS INTERMEDIATES | CYP1A1, CYP2E1, CYP1B1 | EDNRB 3491/4885EDNRA 1810/4885CNR1 1599/4885 |
| US-20140135508-A1 | SPIRO EPOXIDES AS INTERMEDIATES | CYP1A1, CYP2E1, GSTO1 | EDNRB 4107/4885EDNRA 2919/4885CNR1 1512/4885 |
| US-20130137573-A1 | HERBICIDAL COMPOSITIONS COMPRISING, AND METHODS OF USE OF, HERBICIDALLY ACTIVE PYRANDIONES | FOXM1, ARSA, RPS21 | EDNRB 2387/4885EDNRA 2144/4885CNR1 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.