Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698265 | 0.81 | ALDH1A1 (0.46) | MAPTTDP1L3MBTL1HTR1AADRA1D | |
| SCHEMBL17028384 | 0.80 | LMNA (0.53) | MAPTL3MBTL1GAA | |
| SCHEMBL23206536 | 0.78 | HTR2C (0.54) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL339812 | 0.78 | MAPT (0.71) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL11229037 | 0.77 | MRGPRX4 (0.47) | SLC6A4HTR2CHTR2B | |
| SCHEMBL8693136 | 0.76 | MAOB (0.59) | APP | |
| SCHEMBL93243 | 0.74 | CA1 (0.54) | MAPK1TDP1L3MBTL1SLC6A4 | |
| SCHEMBL4621113 | 0.74 | TSHR (0.44) | MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL335356 | 0.74 | TSHR (0.44) | MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL791853 | 0.72 | HTR1A (0.74) | MAPTMAPK1TDP1L3MBTL1LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756507-A | TREATING SEX HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |
| US-3998953-A | 1,3,7-Trisubstitued xanthine peripheral vasodilators | BOEHRINGER INGELHEIM GMBH (DT) | 1976-12-21 | — | — | US | disclosed |