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Propionic Acid

Propionic Acid

SCHEMBL8698740

CCC(=O)O.N=C(N)Nc1cccc(-c2c(Cl)cc(N)c(S(=O)(=O)c3ccccc3NC=O)c2Cl)c1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC6 Q9UBN7 1/20 0.33
▸ MET P08581 5/20 0.32
▸ ALK Q9UM73 5/20 0.32
▸ ITGB3 P05106 1/20 0.32
▸ ITGAV P06756 1/20 0.32
▸ RORC P51449 1/20 0.31
▸ F10 P00742 2/20 0.31
▸ ACLY P53396 1/20 0.30
▸ C1S P09871 1/20 0.30
▸ PTGDR2 Q9Y5Y4 1/20 0.30
▸ UBE2N P61088 1/20 0.30
▸ PAX8 Q06710 1/20 0.30
▸ LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8698654 0.74 PTGER1 (0.34) HDAC1HDAC6ITGB3F10
SCHEMBL8696209 0.74 ATR (0.34) HDAC1HDAC6ITGB3F10
Propionic Acid SCHEMBL8534857 0.66 USP28 (0.40) LMNA
SCHEMBL8429164 0.66 RXFP1 (0.36) METALKF10
SCHEMBL8428869 0.63 DHODH (0.34) HDAC6ITGB3ITGAVF10PAX8
SCHEMBL8531719 0.63 ITGB3 (0.38) ITGB3
SCHEMBL8693773 0.62 RXFP1 (0.40) LMNA
SCHEMBL8694013 0.62 RXFP1 (0.39) LMNA
SCHEMBL8496957 0.61 MEN1 (0.43) LMNA
SCHEMBL8432249 0.61 CYP17A1 (0.35) HDAC1HDAC6ITGB3ITGAVACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5843906-A Meta-substituted phenylene sulphonamide derivatives G. D. SEARLE & CO. (US) 1998-12-01 — — US disclosed