Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14886606 | 0.81 | ALOX15 (0.50) | ALOX15HTTTGFBR1KDM4EKDM6B | |
| SCHEMBL5831775 | 0.80 | ADORA3 (0.51) | ALOX15HTTTGFBR1KDM4EKDM6B | |
| SCHEMBL14886809 | 0.80 | ALOX15 (0.49) | ALOX15HTTTGFBR1KDM4EKDM6B | |
| SCHEMBL8700409 | 0.79 | KAT6A (0.44) | JAK1TYK2GRM5MAPTGAA | |
| SCHEMBL8704331 | 0.79 | SLC6A3 (0.50) | PTGS2JAK1TYK2GRM5MAPT | |
| Hydrochloric Acid SCHEMBL8894574 | 0.79 | JAK1 (0.41) | JAK1TYK2KDM4EKDM5CALDH1A1 | |
| SCHEMBL13117413 | 0.79 | ALOX15 (0.50) | ALOX15HTTTGFBR1KDM4EKDM6B | |
| SCHEMBL22636873 | 0.78 | ALPL (0.52) | PTGS2KDM4EPOLBMAPTALDH1A1 | |
| SCHEMBL22636820 | 0.78 | PTGS2 (0.44) | PTGS2JAK1TYK2TGFBR1KDM4E | |
| SCHEMBL29430653 | 0.78 | ALPL (0.52) | PTGS2KDM4EPOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693672-A | 3,4,5-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-02 | — | — | US | disclosed |