Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.56 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712176 | 0.79 | GSTA1 (0.63) | TLR7MEN1KMT2ACES2NPC1 | |
| SCHEMBL8709808 | 0.78 | CSNK2A1 (0.50) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL8654976 | 0.77 | FTO (0.45) | TLR7ALDH1A1LMNACYP3A4COMT | |
| SCHEMBL8709073 | 0.76 | KDM4E (0.50) | TLR7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8714018 | 0.75 | KDM4E (0.43) | TLR7MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8709612 | 0.75 | TLR7 (0.42) | TLR7KCNMA1KMT2AALDH1A1LMNA | |
| SCHEMBL8709608 | 0.75 | TLR7 (0.42) | TLR7KCNMA1KMT2AALDH1A1LMNA | |
| SCHEMBL8711999 | 0.74 | TRPA1 (0.42) | TLR7NPC1RAB9ACYP1A2CYP2C9 | |
| SCHEMBL8709049 | 0.74 | MAPT (0.53) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL5992479 | 0.74 | CNR2 (0.55) | MEN1KMT2AP2RX1CES2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |