Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8719336 | 0.83 | — | — | |
| SCHEMBL8719264 | 0.78 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL8721026 | 0.73 | ALDH1A1 (0.33) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL8475719 | 0.71 | HCAR3 (0.32) | HCAR3 | |
| SCHEMBL8716367 | 0.69 | ALDH1A1 (0.36) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL8715780 | 0.62 | HCAR3 (0.33) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL8473766 | 0.57 | ALDH1A1 (0.32) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL25587995 | 0.56 | EGFR (0.60) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL15926201 | 0.54 | FDPS (0.51) | ALDH1A1TP53HSP90AA1CYP3A4THRB | |
| SCHEMBL24983884 | 0.53 | CYP1A2 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876379-A1 | FUSED 1,2,4-THIADIAZINE AND FUSED 1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997026265-A1 | FUSED 1,2,4-THIADIAZINE AND FUSED 1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-07-24 | — | — | WO | disclosed |