Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rac-3-N-Butylphthalide SCHEMBL27598974 | 0.89 | MAOB (0.53) | — | |
| Rac-3-N-Butylphthalide SCHEMBL22551101 | 0.89 | MAOB (0.53) | — | |
| Rac-3-N-Butylphthalide SCHEMBL716879 | 0.89 | MAOB (0.53) | — | |
| (3S)-Butylphthalide SCHEMBL3756573 | 0.89 | MAOB (0.53) | — | |
| Rac-3-N-Butylphthalide SCHEMBL29744491 | 0.88 | MAOB (0.52) | — | |
| SCHEMBL10981573 | 0.88 | CES2 (0.58) | — | |
| Rac-3-N-Butylphthalide SCHEMBL30233285 | 0.88 | MAOB (0.52) | — | |
| Rac-3-N-Butylphthalide SCHEMBL21381341 | 0.88 | MAOB (0.52) | — | |
| Rac-3-N-Butylphthalide SCHEMBL18011112 | 0.88 | MAOB (0.52) | — | |
| Rac-3-N-Butylphthalide SCHEMBL38661001 | 0.88 | MAOB (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115901976-B | Detection method for measuring 3-butyl-1 (3H) -isobenzofuranone related substances by adopting HPLC | 河北菲尼斯生物技术有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-119192109-A | A pharmaceutical composition containing butylphthalide and its preparation method | 成都施贝康生物医药科技有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-115469039-B | Butylphthalide and detection method of related substances thereof | 成都施贝康生物医药科技有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-115453014-B | Detection method of butylphthalide and related substances thereof | 成都施贝康生物医药科技有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-116874453-A | Butylphthalide impurity compound, preparation method and application thereof | 广东隆赋药业股份有限公司 | 2023-10-13 | — | — | CN | claimed |
| CN-115932126-A | Detection method for measuring racemization-3-n-butylphthalide related substances by HPLC | 河北菲尼斯生物技术有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-115901976-A | Detection method for measuring 3-butyl-1 (3H) -isobenzofuranone related substances by adopting HPLC | 河北菲尼斯生物技术有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-115554289-A | Pharmaceutical active composition containing butylphthalide and preparation method thereof | 成都施贝康生物医药科技有限公司 | 2023-01-03 | — | — | CN | claimed |
| CN-115469039-A | Butylphthalide and related substance detection method thereof | 成都施贝康生物医药科技有限公司 | 2022-12-13 | — | — | CN | claimed |
| CN-115453014-A | Detection method of butylphthalide and related substances thereof | 成都施贝康生物医药科技有限公司 | 2022-12-09 | — | — | CN | claimed |
| CN-110320293-B | Method for determining residual solvent in phthalide compound | 弘和制药有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-110221009-B | Method for measuring butylphthalide related substances by HPLC | 北京澳合药物研究院有限公司 | 2020-04-17 | — | — | CN | claimed |
| CN-110108818-B | High performance liquid chromatography for high performance separation detection of phthalide derivatives and application thereof | 北京澳合药物研究院有限公司 | 2020-03-17 | — | — | CN | claimed |
| CN-110320293-A | A kind of method of residual solvent in measurement phthalide analog compound | 北京澳合药物研究院有限公司 | 2019-10-11 | — | — | CN | claimed |
| CN-110221009-A | A kind of HPLC measurement method of the butylphenyl phthaleine in relation to substance | 北京澳合药物研究院有限公司 | 2019-09-10 | — | — | CN | claimed |
| CN-110108818-A | A kind of high performance liquid chromatography and its application efficiently separating detection phthalide derivant | 北京澳合药物研究院有限公司 | 2019-08-09 | — | — | CN | claimed |
| US-20150045564-A1 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-12 | — | — | US | claimed |
| WO-2013102935-A2 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-07-11 | — | — | WO | claimed |
| US-4902809-A | Method for making N-substituted nitrophthalimides | GENERAL ELECTRIC COMPANY (US) | 1990-02-20 | — | — | US | claimed |
| CN-121081457-A | A pharmaceutical composition containing butylphthalide and its preparation method | 成都施贝康生物医药科技有限公司 | 2025-12-09 | — | — | CN | disclosed |
| CN-115932126-B | Detection method for measuring racemization-3-n-butylphthalide related substances by HPLC | 河北菲尼斯生物技术有限公司 | 2025-06-06 | — | — | CN | disclosed |
| CN-119751392-A | Benzofuran compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 南方医科大学 | 2025-04-04 | — | — | CN | disclosed |
| CN-115901976-B | Detection method for measuring 3-butyl-1 (3H) -isobenzofuranone related substances by adopting HPLC | 河北菲尼斯生物技术有限公司 | 2025-03-25 | — | — | CN | disclosed |
| CN-119192109-A | A pharmaceutical composition containing butylphthalide and its preparation method | 成都施贝康生物医药科技有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-119192109-A | A pharmaceutical composition containing butylphthalide and its preparation method | 成都施贝康生物医药科技有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-118393015-A | Detection method of butylphthalide related substances | 广东隆赋药业股份有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-115469039-B | Butylphthalide and detection method of related substances thereof | 成都施贝康生物医药科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-115453014-B | Detection method of butylphthalide and related substances thereof | 成都施贝康生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116903564-A | Butylphthalide impurity, and preparation method, analysis method and application thereof | 石药集团恩必普药业有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116874453-A | Butylphthalide impurity compound, preparation method and application thereof | 广东隆赋药业股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-116239602-A | Impurity A in 3-butyl-1 (3H) -isobenzofuranone, and preparation method, detection method and application thereof | 河北赛谱睿思医药科技有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-115932126-A | Detection method for measuring racemization-3-n-butylphthalide related substances by HPLC | 河北菲尼斯生物技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-115932126-A | Detection method for measuring racemization-3-n-butylphthalide related substances by HPLC | 河北菲尼斯生物技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-115901976-A | Detection method for measuring 3-butyl-1 (3H) -isobenzofuranone related substances by adopting HPLC | 河北菲尼斯生物技术有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115554289-A | Pharmaceutical active composition containing butylphthalide and preparation method thereof | 成都施贝康生物医药科技有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-115554289-A | Pharmaceutical active composition containing butylphthalide and preparation method thereof | 成都施贝康生物医药科技有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-115469039-A | Butylphthalide and related substance detection method thereof | 成都施贝康生物医药科技有限公司 | 2022-12-13 | — | — | CN | disclosed |
| CN-115453014-A | Detection method of butylphthalide and related substances thereof | 成都施贝康生物医药科技有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-109111415-B | Dendrobium alkaloid derivative, preparation method and medical application | 安徽中医药大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-110320293-B | Method for determining residual solvent in phthalide compound | 弘和制药有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-111423400-A | Preparation method of high-stability 3-butyl-1 (3H) -isobenzofuranone | 河北菲尼斯生物技术有限公司 | 2020-07-17 | — | — | CN | disclosed |
| CN-110221009-B | Method for measuring butylphthalide related substances by HPLC | 北京澳合药物研究院有限公司 | 2020-04-17 | — | — | CN | disclosed |
| CN-110108818-B | High performance liquid chromatography for high performance separation detection of phthalide derivatives and application thereof | 北京澳合药物研究院有限公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-110320293-A | A kind of method of residual solvent in measurement phthalide analog compound | 北京澳合药物研究院有限公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-110221009-A | A kind of HPLC measurement method of the butylphenyl phthaleine in relation to substance | 北京澳合药物研究院有限公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-110108818-A | A kind of high performance liquid chromatography and its application efficiently separating detection phthalide derivant | 北京澳合药物研究院有限公司 | 2019-08-09 | — | — | CN | disclosed |
| US-9358191-B2 | Deodorant composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2016-06-07 | — | — | US | disclosed |
| US-9309250-B2 | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-04-12 | — | — | US | disclosed |
| US-8961946-B2 | Hair processing agent and method for permanent waving hair | SHOWA DENKO K.K. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20150045564-A1 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-12 | — | — | US | disclosed |
| US-20140271522-A1 | DEODORANT COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2014-09-18 | — | — | US | disclosed |
| US-8778320-B2 | Deodorant composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2014-07-15 | — | — | US | disclosed |
| EP-1561476-B1 | DEODORANT COMPOSITION | TAKASAGO PERFUMERY CO LTD (JP) | 2014-02-12 | — | — | EP | disclosed |
| EP-2618856-A1 | DEODORANT COMPOSITION FOR SULFIDES | Takasago International Corporation (JP) | 2013-07-31 | — | — | EP | disclosed |
| WO-2013102935-A2 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-07-11 | — | — | WO | disclosed |
| US-20130136713-A1 | DEODORANT COMPOSITION FOR SULFIDES | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-05-30 | — | — | US | disclosed |
| US-20130034616-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-07 | — | — | US | disclosed |
| CN-102716121-A | Butylphthalide medicinal active composition and preparation method thereof | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2012-10-10 | — | — | CN | disclosed |
| WO-2012039516-A1 | DEODORANT COMPOSITION FOR SULFIDES | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-03-29 | — | — | WO | disclosed |
| US-20090087401-A1 | DEODORANT COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2009-04-02 | — | — | US | disclosed |
| US-20080085251-A1 | even at a neutral to weakly acidic pH; a lactone or lactam having a mercapto group; with thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine; | RESONAC CORPORATION (JP) | 2008-04-10 | — | — | US | disclosed |
| EP-1827370-A1 | HAIR PROCESSING AGENT AND METHOD FOR PERMANENT WAVING HAIR | Showa Denko K.K. (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-20060165622-A1 | Deodorant composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2006-07-27 | — | — | US | disclosed |
| WO-2006068276-A1 | HAIR PROCESSING AGENT AND METHOD FOR PERMANENT WAVING HAIR | SHOWA DENKO K.K. (JP) | 2006-06-29 | — | — | WO | disclosed |
| EP-1561476-A1 | DEODORANT COMPOSITION | Takasago International Corporation (JP) | 2005-08-10 | — | — | EP | disclosed |
| US-6326006-B1 | ACCELERATING BLOOD CIRCULATION, BODY WARMING AND RETENTION OF WARMTH; COMPRISES ALKYL PHTHALIDE, ALKOXY PHTHALIDE, ALKYLIDENE PHTHALIDE OR MIXTURE | KAO CORPORATION (JP) | 2001-12-04 | — | — | US | disclosed |
| EP-0357081-B1 | Bathing preparation | KAO CORP (JP) | 1995-01-04 | — | — | EP | disclosed |
| EP-0357081-A2 | Bathing preparation | Kao Corporation (JP) | 1990-03-07 | — | — | EP | disclosed |
| EP-0357081-A2 | Bathing preparation | Kao Corporation (JP) | 1990-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045564-A1 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | SOD1, AOC2, SOD3 | ALDH1A1 97/4885LMNA 4449/4885MEN1 407/4885 |
| US-20080085251-A1 | even at a neutral to weakly acidic pH; a lactone or lactam having a mercapto group; with thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine; | TST, CYSLTR1, CYSLTR2 | ALDH1A1 672/4885LMNA 4594/4885MEN1 4606/4885 |
| US-20130034616-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | ALDH1A1 3823/4885LMNA 2095/4885MEN1 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.