Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 9/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882496 | 0.90 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8729332 | 0.90 | BCHE (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8729317 | 0.90 | OPRM1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8729353 | 0.88 | MMP2 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8734166 | 0.87 | BACE1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8734156 | 0.83 | MME (0.40) | — | |
| SCHEMBL8734199 | 0.83 | MMP1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8729343 | 0.79 | LAP3 (0.45) | NPC1RAB9A | |
| SCHEMBL8731465 | 0.71 | BACE1 (0.50) | — | |
| SCHEMBL7322817 | 0.71 | BACE1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708004-A | ENZYME INHIBITORS FOR TREATMENT OF AIDS | MONSANTO COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| US-5703076-A | TREATING HIV, AIDS | G. D. SEARLE & CO. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5698569-A | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5510349-A | HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5510487-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5510378-A | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |