SCHEMBL873220

SCHEMBL873220

O=[C]c1ccccc1CO

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.44
APOBEC3G Q9HC16 1/20 0.43
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
HPGD P15428 3/20 0.36
LMNA P02545 1/20 0.36
GAA P10253 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CYP4F2 P78329 2/20 0.35
CYP4A11 Q02928 2/20 0.35
ALDH1A1 P00352 2/20 0.35
TSHR P16473 1/20 0.35
CYP2A6 P11509 1/20 0.34
MAOB P27338 1/20 0.34
TDP1 Q9NUW8 1/20 0.32
AKR1B1 P15121 1/20 0.32
HSPA5 P11021 1/20 0.32
MAPT P10636 1/20 0.32
MPI P34949 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL535892 0.78 GABRA1 (0.45) FFAR1GAAL3MBTL1ALDH1A1MAPT
SCHEMBL30496165 0.76 ALDH1A1 (0.49) FFAR1APOBEC3GLMNAALDH1A1TSHR
SCHEMBL149728 0.76 APOBEC3G (0.43) FFAR1APOBEC3GPDCD1CD274HPGD
SCHEMBL3021179 0.76 TRPA1 (0.35) ALDH1A1TSHR
SCHEMBL9317847 0.76 FFAR1 (0.31) FFAR1HPGDALDH1A1
SCHEMBL5750300 0.76 APOBEC3G (0.43) FFAR1APOBEC3GPDCD1CD274HPGD
SCHEMBL3644028 0.76 PNMT (0.44) CYP2A6
SCHEMBL1379506 0.76 ALDH1A1 (0.42) ALDH1A1TSHR
SCHEMBL21410141 0.76 APOBEC3G (0.43) FFAR1APOBEC3GPDCD1CD274HPGD
SCHEMBL1465518 0.76 GABRA1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 381 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4251632-A1 COMPOSITIONS AND METHODS FOR CHEMICAL SYNTHESIS Sederma (FR) 2023-10-04 EP claimed
WO-2022115825-A1 COMPOSITIONS AND METHODS FOR CHEMICAL SYNTHESIS GAP PEPTIDES, LLC (US) 2022-06-02 WO claimed
EP-2643000-A2 THERAPEUTIC PIPERAZINES Dart Neuroscience (Cayman) Ltd (KY) 2013-10-02 EP claimed
WO-2012040258-A2 THERAPEUTIC PIPERAZINES HELICON THERAPEUTICS, INC. (US) 2012-03-29 WO claimed
US-20110065691-A1 THERAPEUTIC PIPERAZINES DART NEUROSCIENCE (CAYMAN) LTD. (KY) 2011-03-17 US claimed
US-6888001-B2 Selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function. LEE JUNG S (US) 2005-05-03 US claimed
EP-1107965-B1 PYRIDYL ETHERS AND THIOETHERS AS LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS THERAPEUTIC APPLICATION ORTHO MCNEIL PHARM INC (US) 2004-08-11 EP claimed
US-20030207858-A1 Selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function. LEE JUNG S (US) 2003-11-06 US claimed
CN-1125064-C 3-pyridyl enantiomers and their use as analgesics ABBOTT LAB (US) 2003-10-22 CN claimed
EP-0950057-B1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LAB (US) 2002-11-13 EP claimed
EP-1107965-A1 PYRIDYL ETHERS AND THIOETHERS AS LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS THERAPEUTIC APPLICATION Ortho-McNeil Pharmaceutical, Inc. (US) 2001-06-20 EP claimed
WO-2000010997-A1 PYRIDYL ETHERS AND THIOETHERS AS LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS THERAPEUTIC APPLICATION ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2000-03-02 WO claimed
CN-1245496-A 3-pyridyl enantiomers and their use as analgesics ABBOTT LAB (US) 2000-02-23 CN claimed
EP-0950057-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS Abbott Laboratories (US) 1999-10-20 EP claimed
WO-1998025920-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LABORATORIES (US) 1998-06-18 WO claimed
EP-0357082-B1 Silver halide photographic emulsions FUJI PHOTO FILM CO LTD (JP) 1996-12-11 EP claimed
US-4971889-A Spectral sensitizing dye containnig a hydrazine residue FUJI PHOTO FILM CO., LTD. (JP) 1990-11-20 US claimed
EP-0357082-A2 Silver halide photographic emulsions FUJI PHOTO FILM CO., LTD. (JP) 1990-03-07 EP claimed
EP-4370528-A1 AQUEOUS SOLID PHASE PEPTIDE SYNTHESIS Polypeptide Laboratories Holding (PPL) AB (SE) 2024-05-22 EP disclosed
EP-0357082-A2 Silver halide photographic emulsions FUJI PHOTO FILM CO., LTD. (JP) 1990-03-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030207858-A1 Selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function. CHRM1, CHRM5, CHRM2 FFAR1 358/4885APOBEC3G 4790/4885PDCD1 4266/4885
US-20110065691-A1 THERAPEUTIC PIPERAZINES PDE4A, PDE4B, PDE4D FFAR1 1069/4885APOBEC3G 4406/4885PDCD1 3658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.