Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | DGKA | P23743 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276446 | 0.95 | TSHR (0.73) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL12558002 | 0.95 | TSHR (0.73) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL5476493 | 0.94 | TSHR (0.58) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL11233083 | 0.93 | TSHR (0.76) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL19165635 | 0.91 | TSHR (0.65) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL19627098 | 0.91 | TSHR (0.65) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL9100632 | 0.89 | TSHR (0.83) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL2534124 | 0.89 | TSHR (0.61) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL23553096 | 0.89 | DGKA (0.66) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL14792967 | 0.89 | DGKA (0.66) | TSHRALDH1A1TP53HIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697804-B2 | Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-07-11 | — | — | US | disclosed |
| US-20180177881-A1 | Multicomponent Degradable Cationic Polymers | THE JOHNS HOPKINS UNIVERSITY | 2018-06-28 | — | — | US | disclosed |
| US-20180134753-A1 | BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES | THE JOHNS HOPKINS UNIVERSITY | 2018-05-17 | — | — | US | disclosed |
| US-20180112038-A1 | POLY(BETA-AMINO ESTER)-CO-POLYETHYLENE GLYCOL (PEG-PBAE-PEG) POLYMERS FOR GENE AND DRUG DELIVERY | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-04-26 | — | — | US | disclosed |
| US-9884118-B2 | Multicomponent degradable cationic polymers | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-02-06 | — | — | US | disclosed |
| US-20180028455-A1 | PEPTIDE/PARTICLE DELIVERY SYSTEMS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-01 | — | — | US | disclosed |
| US-9802984-B2 | Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-31 | — | — | US | disclosed |
| US-9717694-B2 | Peptide/particle delivery systems | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170143639-A1 | NANOCOMPOSITES OF GOLD AND POLYMERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-05-25 | — | — | US | disclosed |
| US-20160374949-A9 | PEPTIDE/PARTICLE DELIVERY SYSTEMS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-12-29 | — | — | US | disclosed |
| US-20160122390-A1 | A BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-05 | — | — | US | disclosed |
| US-20150273071-A1 | Bioreducible Poly (Beta-Amino Ester)s For siRNA Delivery | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-10-01 | — | — | US | disclosed |
| US-20150272900-A1 | Layer-By-Layer Approach to Co-Deliver DNA and siRNA via AuNPs: A Potential Platform for Modifying Release Kinetics | THE JOHNS HOPKINS UNIVERSITY | 2015-10-01 | — | — | US | disclosed |
| US-20150250881-A1 | Multicomponent Degradable Cationic Polymers | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-09-10 | — | — | US | disclosed |
| US-8992991-B2 | Multicomponent degradable cationic polymers | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140294909-A1 | NANOCOMPOSITES OF GOLD AND POLYMERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-10-02 | — | — | US | disclosed |
| US-20120128782-A1 | Multicomponent Degradable Cationic Polymers | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120114759-A1 | PEPTIDE/PARTICLE DELIVERY SYSTEMS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-05-10 | — | — | US | disclosed |
| US-20070031499-A1 | Readily shapeable xerogels having controllably delayed swelling properties | AKINA, INC. | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160374949-A9 | PEPTIDE/PARTICLE DELIVERY SYSTEMS | VEGFA, IAPP, FLT1 | TSHR 2490/4885ALDH1A1 4007/4885TP53 324/4885 |
| US-20160122390-A1 | A BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES | VEGFA, LRRFIP1, FLT1 | TSHR 2524/4885ALDH1A1 3688/4885TP53 1814/4885 |
| US-20150272900-A1 | Layer-By-Layer Approach to Co-Deliver DNA and siRNA via AuNPs: A Potential Platform for Modifying Release Kinetics | DNMT3L, DBNL, HNRNPL | TSHR 2581/4885ALDH1A1 2087/4885TP53 892/4885 |
| US-20150250881-A1 | Multicomponent Degradable Cationic Polymers | PEF1, FIBP, PARN | TSHR 3568/4885ALDH1A1 3684/4885TP53 65/4885 |
| US-20070031499-A1 | Readily shapeable xerogels having controllably delayed swelling properties | SMARCA2, SMARCA4, SMARCE1 | TSHR 1677/4885ALDH1A1 4329/4885TP53 1189/4885 |
| US-20180177881-A1 | Multicomponent Degradable Cationic Polymers | PEF1, FIBP, PARN | TSHR 3568/4885ALDH1A1 3684/4885TP53 65/4885 |
| US-20170143639-A1 | NANOCOMPOSITES OF GOLD AND POLYMERS | HNRNPL, HNRNPLL, ACSL3 | TSHR 1764/4885ALDH1A1 883/4885TP53 1592/4885 |
| US-20150273071-A1 | Bioreducible Poly (Beta-Amino Ester)s For siRNA Delivery | AARS1, SLC43A1, PHAX | TSHR 4597/4885ALDH1A1 3187/4885TP53 1588/4885 |
| US-20120114759-A1 | PEPTIDE/PARTICLE DELIVERY SYSTEMS | VEGFA, IAPP, FLT1 | TSHR 2490/4885ALDH1A1 4007/4885TP53 324/4885 |
| US-20180112038-A1 | POLY(BETA-AMINO ESTER)-CO-POLYETHYLENE GLYCOL (PEG-PBAE-PEG) POLYMERS FOR GENE AND DRUG DELIVERY | PBDC1, BCAT1, PBRM1 | TSHR 3297/4885ALDH1A1 2856/4885TP53 178/4885 |
| US-20120128782-A1 | Multicomponent Degradable Cationic Polymers | PEF1, FIBP, PARN | TSHR 3568/4885ALDH1A1 3684/4885TP53 65/4885 |
| US-20180134753-A1 | BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES | VEGFA, LRRFIP1, FLT1 | TSHR 2635/4885ALDH1A1 3587/4885TP53 1625/4885 |
| US-11697804-B2 | Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy | POLRMT, HDGF, PCNP | TSHR 3981/4885ALDH1A1 3433/4885TP53 15/4885 |
| US-20180028455-A1 | PEPTIDE/PARTICLE DELIVERY SYSTEMS | VEGFA, IAPP, FLT1 | TSHR 2490/4885ALDH1A1 4007/4885TP53 324/4885 |
| US-20140294909-A1 | NANOCOMPOSITES OF GOLD AND POLYMERS | HNRNPL, HNRNPLL, ACSL3 | TSHR 1764/4885ALDH1A1 883/4885TP53 1592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.