SCHEMBL8738485

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL21671197	0.92	THRB (0.41)	TSHRALDH1A1THRBEPHX1CA1
	SCHEMBL8738483	0.92	THRB (0.41)	TSHRALDH1A1THRBEPHX1CA1
	SCHEMBL8737819	0.90	TSHR (0.44)	TSHRALDH1A1TP53HIF1AHSD17B10
	SCHEMBL18123361	0.90	TSHR (0.44)	TSHRALDH1A1TP53HIF1AHSD17B10
	SCHEMBL8738995	0.89	TSHR (0.41)	TSHRALDH1A1THRBEPHX1NPC1
	SCHEMBL14048840	0.89	THRB (0.39)	TSHRALDH1A1THRBEPHX1CA1
	SCHEMBL18123480	0.89	TSHR (0.44)	TSHRTHRBEPHX1NAAA
	SCHEMBL18123481	0.89	THRB (0.45)	TSHRALDH1A1THRBEPHX1CA1
	SCHEMBL18123478	0.87	TSHR (0.45)	TSHRTHRBEPHX1NAAA
	SCHEMBL8738965	0.87	TSHR (0.42)	TSHRALDH1A1THRBEPHX1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.