Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.40 |
| ▸ | Q9HBH1 | 1/20 | 0.40 | |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423862 | 1.00 | MMP2 (0.53) | MMP2MAPTCRHBPCRHR2L3MBTL1 | |
| SCHEMBL2387943 | 1.00 | MMP2 (0.53) | MMP2MAPTCRHBPCRHR2L3MBTL1 | |
| SCHEMBL28783978 | 0.90 | MMP2 (0.49) | MMP2MAPTCRHBPCRHR2L3MBTL1 | |
| SCHEMBL9840744 | 0.82 | BCL9 (0.50) | MAPTCRHBPCRHR2L3MBTL1BCL9 | |
| SCHEMBL7275811 | 0.82 | BCL9 (0.50) | MAPTCRHBPCRHR2L3MBTL1BCL9 | |
| SCHEMBL28323255 | 0.81 | BCL9 (0.51) | MAPTCRHBPCRHR2BCL9CTNNB1 | |
| SCHEMBL712246 | 0.81 | MMP2 (0.46) | MMP2MAPTKMT2AALDH1A1 | |
| SCHEMBL18941468 | 0.81 | PDF (0.48) | MMP2MAPTCRHBPCRHR2L3MBTL1 | |
| SCHEMBL18941467 | 0.81 | PDF (0.48) | MMP2MAPTCRHBPCRHR2L3MBTL1 | |
| SCHEMBL9819573 | 0.81 | BCL9 (0.47) | MMP2MAPTCRHBPCRHR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715619-A4 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0715619-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1996-06-12 | — | — | EP | disclosed |
| EP-0002677-B1 | GLUCOSAMINE-PEPTIDE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS | Takeda Chemical Industries, Ltd. (JP) | 1982-10-13 | — | — | EP | disclosed |