Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594891 | 1.00 | TAS1R3 (0.49) | TAS1R3TAS1R1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL6993048 | 0.91 | TAS1R3 (0.44) | TAS1R3TAS1R1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL7950138 | 0.91 | TAS1R3 (0.44) | TAS1R3TAS1R1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL7964617 | 0.90 | TAS1R3 (0.48) | TAS1R3TAS1R1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL6990364 | 0.90 | TAS1R3 (0.48) | TAS1R3TAS1R1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL8744786 | 0.90 | ALDH1A1 (0.42) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2THRB | |
| SCHEMBL9595171 | 0.90 | ALDH1A1 (0.42) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2THRB | |
| SCHEMBL8744706 | 0.85 | THRA (0.45) | NPSR1THRBMEN1KMT2APSMB5 | |
| SCHEMBL8744704 | 0.85 | THRA (0.45) | NPSR1THRBMEN1KMT2APSMB5 | |
| SCHEMBL27407409 | 0.82 | TAS1R3 (0.44) | TAS1R3TAS1R1ALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |