SCHEMBL8746003

SCHEMBL8746003

Cc1cc(NCCO)cc(C)c1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
MAPK1 P28482 3/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
GAA P10253 2/20 0.42
TSHR P16473 1/20 0.38
KDM4E B2RXH2 2/20 0.38
HSD17B10 Q99714 1/20 0.38
PKM P14618 2/20 0.36
POLB P06746 2/20 0.36
SOS1 Q07889 1/20 0.36
SLC2A1 P11166 1/20 0.35
HTT P42858 1/20 0.35
GRIN2D O15399 1/20 0.35
GRIN3B O60391 1/20 0.35
CHRM1 P11229 1/20 0.35
ADRA1D P25100 1/20 0.35
ADRA1A P35348 1/20 0.35
ADRA1B P35368 1/20 0.35
GRIN1 Q05586 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL849826 0.81 ALDH1A1 (0.46) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL16302318 0.81 ALDH1A1 (0.46) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL18589183 0.78 MAPK1 (0.42) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL109784 0.78 ALDH1A1 (0.47) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL5187258 0.77 THRB (0.50) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL4863544 0.77 THRB (0.55) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL4466255 0.77 ALDH1A1 (0.76) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL20565124 0.77 ADRA2A (0.42) ALDH1A1MAPK1TSHRPOLBSOS1
SCHEMBL18739206 0.75 KCNH3 (0.39) ALDH1A1MAPK1KMT2AMEN1GAA
SCHEMBL4466574 0.74 ALDH1A1 (0.56) ALDH1A1MAPK1KMT2AMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0488756-B1 Oxidizable color producing reagent WAKO PURE CHEM IND LTD (JP) 1997-02-26 EP disclosed
US-5238818-A Derivative of p-fluoroaniline with 4-aminoantipyrine WAKO PURE CHEMICALS CO., LTD. (JP) 1993-08-24 US disclosed
EP-0488756-A1 Oxidizable color producing reagent WAKO PURE CHEMICAL INDUSTRIES LTD (JP) 1992-06-03 EP disclosed