Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21935248 | 0.77 | ACHE (0.59) | MAOBMAOAACHESLC6A2SLC6A4 | |
| SCHEMBL8747865 | 0.77 | OPRM1 (0.41) | MAOBMAOAACHETDP1PNMT | |
| SCHEMBL21264045 | 0.73 | OPRM1 (0.42) | MAOBMAOAACHETDP1OPRM1 | |
| SCHEMBL21935244 | 0.69 | ALDH1A1 (0.46) | MAOBMAOAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22996210 | 0.67 | SIGMAR1 (0.39) | OPRM1OPRK1OPRL1KMT2AOPRD1 | |
| SCHEMBL15043554 | 0.66 | MGAT2 (0.33) | MAOBMAOASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15043553 | 0.66 | MAOB (0.40) | MAOBMAOAOPRM1SLC6A2SLC6A4 | |
| SCHEMBL8297045 | 0.65 | ACHE (0.44) | MAOBMAOAACHETDP1OPRM1 | |
| SCHEMBL11138307 | 0.65 | NPC1 (0.41) | MAOBMAOAACHETDP1OPRM1 | |
| SCHEMBL12981749 | 0.65 | LMNA (0.40) | MAOBMAOAACHETDP1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599732-B1 | Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them | ADIR (FR) | 1997-03-12 | — | — | EP | disclosed |
| US-5403953-A | Antiarthritic and -inflammatory agents | ADIR ET COMPAGNIE (FR) | 1995-04-04 | — | — | US | disclosed |
| EP-0599732-A1 | Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-06-01 | — | — | EP | disclosed |