Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8762997 | 0.91 | RIPK1 (0.38) | ALDH1A1RIPK1HSD11B1 | |
| SCHEMBL8763886 | 0.85 | P2RX7 (0.37) | RIPK1P2RX7 | |
| SCHEMBL8764701 | 0.84 | HSD11B1 (0.37) | HSD11B1MEN1KMT2A | |
| SCHEMBL8763626 | 0.83 | GRM2 (0.36) | TRPA1LTB4RLTB4R2RIPK1P2RX7 | |
| SCHEMBL8763834 | 0.82 | — | — | |
| SCHEMBL8763796 | 0.80 | GRM2 (0.35) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8762717 | 0.79 | GRM2 (0.44) | ALDH1A1P2RX7KMT2A | |
| SCHEMBL8762591 | 0.78 | HSD11B1 (0.37) | ALDH1A1P2RX7HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL8763981 | 0.76 | P2RX7 (0.40) | P2RX7 | |
| SCHEMBL8762671 | 0.76 | MAOA (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0774455-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1997-05-21 | — | — | EP | disclosed |