SCHEMBL8765659

SCHEMBL8765659

CCc1cccc(N2C(=O)C(Cl)=C(Cl)C2=O)c1CC

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.49
MGLL Q99685 1/20 0.44
HTR1A P08908 2/20 0.41
DRD2 P14416 2/20 0.41
DRD4 P21917 2/20 0.41
HTR2A P28223 2/20 0.41
HTR2C P28335 2/20 0.41
DRD3 P35462 2/20 0.41
TSHR P16473 1/20 0.41
KDM5A P29375 1/20 0.40
NR1H2 P55055 3/20 0.40
NR1H3 Q13133 1/20 0.39
LMNA P02545 3/20 0.38
BCL2A1 Q16548 1/20 0.38
MAPT P10636 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9980563 0.83 NR1H3 (0.56) MGLLTSHRNR1H2NR1H3LMNA
SCHEMBL8766123 0.83 KDM5A (0.49) PKMMGLLHTR1ADRD2DRD4
SCHEMBL5086724 0.79 MGLL (0.72) PKMMGLLTSHRLMNAMAPT
SCHEMBL2184085 0.78 CRHBP (0.56) PKMMGLLLMNAMAPTCRHBP
SCHEMBL8766121 0.76 NR1H2 (0.56) PKMMGLLTSHRKDM5ANR1H2
SCHEMBL2840556 0.72 L3MBTL1 (0.51) PKMKDM5AMEN1KMT2ACRHBP
SCHEMBL29431569 0.72 L3MBTL1 (0.51) PKMKDM5AMEN1KMT2ACRHBP
SCHEMBL10569820 0.72 LMNA (0.48) PKMMGLLHTR1ADRD2DRD4
SCHEMBL2682479 0.71 POLB (0.52) TSHRBCL2A1MAPTMEN1KMT2A
SCHEMBL28187917 0.71 CRHBP (0.49) PKMMGLLLMNAMAPTCRHBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0425709-B1 UNDERSEA ANTIFOULING AGENT NIPPON OILS & FATS CO LTD (JP) 1997-08-13 EP claimed
US-5229436-A 2-(thiocyanomethylthio)benzothiazole, N-(dialkylphenyl)-dichloromaleimide, film former, and dialkylpolysulfide; ropes NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1993-07-20 US claimed
EP-0425709-A1 UNDERSEA ANTIFOULING AGENT NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1991-05-08 EP claimed
EP-0425709-B1 UNDERSEA ANTIFOULING AGENT NIPPON OILS & FATS CO LTD (JP) 1997-08-13 EP disclosed
US-5290834-A Method for controlling elution rate of agent ROHM & HAAS COMPANY (US) 1994-03-01 US disclosed
US-5229436-A 2-(thiocyanomethylthio)benzothiazole, N-(dialkylphenyl)-dichloromaleimide, film former, and dialkylpolysulfide; ropes NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1993-07-20 US disclosed
EP-0425709-A1 UNDERSEA ANTIFOULING AGENT NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1991-05-08 EP disclosed
EP-0425709-A1 UNDERSEA ANTIFOULING AGENT NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1991-05-08 EP disclosed
WO-1990014011-A1 UNDERSEA ANTIFOULING AGENT NIPPON OIL AND FATS CO., LTD. (JP) 1990-11-29 WO disclosed