Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768350 | 0.91 | MAPT (0.44) | ROCK2ROCK1MAPTTSHRCA1 | |
| SCHEMBL9235404 | 0.90 | MAPT (0.46) | ROCK2MAPTCA1CA2CA7 | |
| SCHEMBL8916374 | 0.88 | ROCK2 (0.48) | ROCK2ROCK1MAPTTSHRALDH1A1 | |
| SCHEMBL8767145 | 0.84 | LMNA (0.47) | MAPTTSHRALDH1A1CA1CA2 | |
| SCHEMBL8766943 | 0.83 | PTGS2 (0.48) | TSHRMCL1PTGS1PTGS2CYSLTR1 | |
| SCHEMBL8767162 | 0.82 | LMNA (0.40) | NAMPTPTGS1PTGS2 | |
| SCHEMBL8768360 | 0.82 | L3MBTL1 (0.50) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8105999 | 0.81 | MAPT (0.47) | MAPTCA1CA2CA7CA9 | |
| SCHEMBL8768258 | 0.81 | CA1 (0.39) | ALDH1A1CA1CA2CA9PTGS1 | |
| SCHEMBL8917687 | 0.81 | MAPT (0.45) | ROCK2ROCK1MAPTTSHRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673931-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 1997-08-13 | — | — | EP | disclosed |
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |