Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105999 | 0.90 | MAPT (0.47) | MAPTBCL2L1MCL1CA1CA2 | |
| SCHEMBL8768266 | 0.90 | ROCK2 (0.46) | MAPTBCL2L1MCL1CA1CA2 | |
| SCHEMBL8768350 | 0.87 | MAPT (0.44) | MAPTBCL2L1MCL1CA1CA2 | |
| SCHEMBL8916345 | 0.86 | EGLN1 (0.51) | MAPTBCL2L1MCL1CA1CA2 | |
| SCHEMBL8768242 | 0.82 | LMNA (0.47) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL8867801 | 0.81 | MAPT (0.52) | MAPTBCL2L1MCL1CA1CA2 | |
| SCHEMBL8768423 | 0.80 | LMNA (0.41) | PTGS1PTGS2SMN1; SMN2HTTEGFR | |
| SCHEMBL8916374 | 0.80 | ROCK2 (0.48) | MAPTBCL2L1MCL1CA1CA2 | |
| SCHEMBL8917687 | 0.78 | MAPT (0.45) | MAPTBCL2L1MCL1CA1CA2 | |
| SCHEMBL7869433 | 0.78 | MAPT (0.50) | MAPTBCL2L1MCL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |