SCHEMBL8767671

SCHEMBL8767671

CCN(c1ccc([N+](=O)[O-])cc1)c1c(Nc2ccc(C#N)cc2)c(=O)c1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 1/20 0.45
MAPT P10636 4/20 0.42
THRB P10828 1/20 0.42
RAB9A P51151 3/20 0.40
KCNJ1 P48048 1/20 0.40
KCNH2 Q12809 1/20 0.40
ALDH1A1 P00352 3/20 0.38
DHODH Q02127 1/20 0.38
LMNA P02545 1/20 0.38
POLB P06746 1/20 0.38
ABCG2 Q9UNQ0 2/20 0.37
MERTK Q12866 1/20 0.37
ADAMTS5 Q9UNA0 1/20 0.37
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
AR P10275 1/20 0.35
CTSL P07711 1/20 0.35
CTSS P25774 1/20 0.35
CTSK P43235 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8768608 0.85 RORC (0.40) CXCR2ALDH1A1ADAMTS5
SCHEMBL8768875 0.84 CXCR2 (0.43) CXCR2MAPTABCG2ADAMTS5NPSR1
SCHEMBL8768956 0.82 ADAMTS5 (0.46) MAPTTHRBRAB9AALDH1A1LMNA
SCHEMBL8768638 0.75 ADAMTS5 (0.44) CXCR2ABCG2ADAMTS5KMT2A
SCHEMBL8767677 0.73 KCNH2 (0.54) CXCR2MAPTTHRBKCNJ1KCNH2
SCHEMBL8870223 0.72 CXCR2 (0.51) CXCR2MAPTTHRBRAB9AKCNJ1
SCHEMBL8870227 0.72 CXCR2 (0.51) CXCR2MAPTTHRBRAB9AKCNJ1
SCHEMBL31257790 0.71 MEN1 (0.61) MAPTTHRBKCNJ1KCNH2ALDH1A1
SCHEMBL8768157 0.68 CXCR2 (0.45) CXCR2MAPTALDH1A1KDM4ENPSR1
SCHEMBL8767798 0.68 ABCC9 (0.53) CXCR2MAPTALDH1A1ADAMTS5KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed