SCHEMBL8768608

SCHEMBL8768608

CCN(c1ccc(C)cc1)c1c(Nc2ccc(C#N)cc2)c(=O)c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RORC P51449 7/20 0.40
ADAMTS5 Q9UNA0 2/20 0.40
ALDH1A1 P00352 1/20 0.39
CYP2A6 P11509 1/20 0.39
HCRTR2 O43614 1/20 0.38
KCNA5 P22460 1/20 0.36
GSK3B P49841 3/20 0.36
CSNK1G2 P78368 2/20 0.36
GSK3A P49840 2/20 0.36
CHEK1 O14757 1/20 0.36
CHEK2 O96017 1/20 0.36
PRKACA P17612 1/20 0.36
RPS6KB1 P23443 1/20 0.36
RPS6KA3 P51812 1/20 0.36
NEK4 P51957 1/20 0.36
PRKCD Q05655 1/20 0.36
ROCK1 Q13464 1/20 0.36
PRKG1 Q13976 1/20 0.36
PKN2 Q16513 1/20 0.36
CDC42BPA Q5VT25 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8768875 0.89 CXCR2 (0.43) RORCADAMTS5CXCR2KDM1A
SCHEMBL8768956 0.87 ADAMTS5 (0.46) ADAMTS5ALDH1A1KCNA5GSK3BHDAC1
SCHEMBL8767671 0.85 CXCR2 (0.45) ADAMTS5ALDH1A1CXCR2
SCHEMBL8768638 0.80 ADAMTS5 (0.44) RORCADAMTS5KCNA5CXCR2KDM1A
SCHEMBL8768157 0.74 CXCR2 (0.45) ALDH1A1KCNA5GSK3BGSK3ACXCR2
SCHEMBL8767798 0.72 ABCC9 (0.53) ADAMTS5ALDH1A1KCNA5CXCR2KDM1A
SCHEMBL8768613 0.71 GSK3B (0.50) ALDH1A1CYP2A6GSK3BCSNK1G2GSK3A
SCHEMBL23573064 0.70 CYP2A6 (0.52) ALDH1A1CYP2A6HCRTR2
SCHEMBL10694580 0.70 ALDH1A1 (0.73) ALDH1A1CYP2A6GSK3BCSNK1G2GSK3A
SCHEMBL4370003 0.69 MAPKAPK2 (0.50) ADAMTS5GSK3BCSNK1G2GSK3ACHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed