Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 9/20 | 0.36 |
| ▸ | RARG | P13631 | 8/20 | 0.36 |
| ▸ | RARA | P10276 | 6/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 6/20 | 0.36 |
| ▸ | RXRB | P28702 | 4/20 | 0.36 |
| ▸ | RXRG | P48443 | 3/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163394 | 0.75 | CA12 (0.49) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL8771776 | 0.70 | RARB (0.43) | TDP2RARBRARGRARACYP26A1 | |
| SCHEMBL8771635 | 0.70 | TDP2 (0.42) | TDP2RARBRARGRARACYP26A1 | |
| SCHEMBL8771825 | 0.66 | RARB (0.41) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL485022 | 0.65 | TDP2 (0.50) | TDP2RARBRARGRARACYP26A1 | |
| SCHEMBL6292577 | 0.63 | RARB (0.51) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL28833405 | 0.63 | CA12 (0.45) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL8771910 | 0.62 | TDP2 (0.43) | TDP2RARBRARGRARACYP26A1 | |
| SCHEMBL23617815 | 0.62 | ACHE (0.60) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL8632757 | 0.61 | AKR1B1 (0.41) | TDP2RARBRARGRARACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |