Water

Water

SCHEMBL8773056

O.Oc1cccc(-c2ccccc2)c1O

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 known ✓ P56524 2/20 0.56
HDAC2 known ✓ Q92769 2/20 0.56
HDAC8 known ✓ Q9BY41 2/20 0.56
HDAC6 known ✓ Q9UBN7 1/20 0.56
EGFR known ✓ P00533 2/20 0.50
MMP8 known ✓ P22894 1/20 0.50
ALOX5 known ✓ P09917 1/20 0.46
PDE4B known ✓ Q07343 2/20 0.43
PDE4A known ✓ P27815 1/20 0.43
PDE4C known ✓ Q08493 1/20 0.43
PDE4D known ✓ Q08499 1/20 0.43
ADORA3 known ✓ P0DMS8 1/20 0.42
ADORA2A known ✓ P29274 1/20 0.42
ADORA1 known ✓ P30542 1/20 0.42
PIK3CA known ✓ P42336 1/20 0.41
ALDH1A1 P00352 4/20 0.65
HPGD P15428 4/20 0.65
HSD17B10 Q99714 4/20 0.65
BCL2L1 Q07817 1/20 0.65
HNF4A P41235 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL94298 0.98 ALDH1A1 (0.68) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
SCHEMBL29365218 0.98 ALDH1A1 (0.68) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
SCHEMBL28750451 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
SCHEMBL2064516 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
Methane SCHEMBL2283545 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
Biphenyl SCHEMBL25432905 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
Catechol SCHEMBL26968121 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
Ammonia Solution, Strong SCHEMBL19405739 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
Hydrochloric Acid SCHEMBL27565418 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4
Hydrogen Sulfide SCHEMBL27403486 0.95 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10BCL2L1HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0459332-B1 Process for producing polycyanoaryl ether powder IDEMITSU KOSAN CO (JP) 1997-10-15 EP claimed