Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774858 | 0.97 | MEN1 (0.44) | CYP3A4SMN1; SMN2MEN1USP2ALDH1A1 | |
| SCHEMBL8774716 | 0.94 | LMNA (0.47) | SMN1; SMN2ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL8774669 | 0.88 | NQO1 (0.44) | SMN1; SMN2ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL8774481 | 0.88 | NFKB1 (0.44) | CYP3A4SMN1; SMN2MEN1USP2ALDH1A1 | |
| SCHEMBL8774239 | 0.85 | HTR2A (0.50) | CYP3A4SMN1; SMN2MEN1USP2ALDH1A1 | |
| SCHEMBL8775147 | 0.84 | NPC1 (0.47) | SMN1; SMN2RAB9AMAPTPKMNPC1 | |
| SCHEMBL8774784 | 0.84 | RAB9A (0.46) | CYP3A4SMN1; SMN2MEN1USP2ALDH1A1 | |
| SCHEMBL8774406 | 0.82 | RARB (0.50) | SMN1; SMN2MEN1USP2ALDH1A1MAPK1 | |
| SCHEMBL8774752 | 0.81 | TAAR1 (0.44) | SMN1; SMN2ALDH1A1LMNARAB9AL3MBTL1 | |
| SCHEMBL9156451 | 0.80 | RAB9A (0.48) | CYP3A4SMN1; SMN2MEN1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |