Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774833 | 0.96 | LMNA (0.44) | ACACBLMNAL3MBTL1HSD17B10HTT | |
| SCHEMBL8774925 | 0.95 | CYP2D6 (0.46) | LMNAL3MBTL1HSD17B10RARARARB | |
| SCHEMBL8774330 | 0.93 | CYP3A4 (0.43) | LMNAL3MBTL1RARARARBRAB9A | |
| SCHEMBL8775001 | 0.91 | PKM (0.42) | LMNARARARARBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8774157 | 0.90 | RAB9A (0.39) | LMNAL3MBTL1HSD17B10DHFRRAB9A | |
| SCHEMBL8774813 | 0.88 | MEN1 (0.42) | LMNASMN1; SMN2ALDH1A1CYP3A4MEN1 | |
| SCHEMBL8774796 | 0.85 | NQO1 (0.41) | LMNADHFRSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8774334 | 0.85 | NPC1 (0.40) | HSD17B10HTTRARARARBRAB9A | |
| SCHEMBL9158993 | 0.83 | ACACB (0.44) | ACACBACACALMNAL3MBTL1HSD17B10 | |
| SCHEMBL8774250 | 0.82 | RARB (0.44) | HSD17B10RARARARBRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |