Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774157 | 0.96 | RAB9A (0.39) | NQO1SMN1; SMN2LMNAGPR84DHFR | |
| SCHEMBL8774833 | 0.89 | LMNA (0.44) | SMN1; SMN2LMNADHFRSLC5A1SLC5A2 | |
| SCHEMBL8775001 | 0.89 | PKM (0.42) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8774813 | 0.86 | MEN1 (0.42) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8774847 | 0.85 | ACACB (0.43) | SMN1; SMN2LMNADHFRSLC5A1SLC5A2 | |
| SCHEMBL8774925 | 0.85 | CYP2D6 (0.46) | SMN1; SMN2LMNAKDM4EHPGDALDH1A1 | |
| SCHEMBL8774180 | 0.85 | TAAR1 (0.47) | MAOBKDM4EHPGDALDH1A1 | |
| SCHEMBL8774330 | 0.83 | CYP3A4 (0.43) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8775165 | 0.83 | TAAR1 (0.42) | LMNAGPR84DHFRTP53 | |
| SCHEMBL8774829 | 0.83 | RAB9A (0.36) | SMN1; SMN2GPR84ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |