Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774847 | 0.96 | ACACB (0.43) | LMNAL3MBTL1HTTHSD17B10DHFR | |
| SCHEMBL8775001 | 0.94 | PKM (0.42) | LMNAALDH1A1CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL8774813 | 0.92 | MEN1 (0.42) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8774925 | 0.91 | CYP2D6 (0.46) | LMNAL3MBTL1HSD17B10MAPTALDH1A1 | |
| SCHEMBL8774796 | 0.89 | NQO1 (0.41) | LMNADHFRALDH1A1SLC5A1SLC5A2 | |
| SCHEMBL8774330 | 0.89 | CYP3A4 (0.43) | LMNAL3MBTL1MAPTALDH1A1RAB9A | |
| SCHEMBL8774157 | 0.85 | RAB9A (0.39) | LMNAL3MBTL1HSD17B10DHFRMAPT | |
| SCHEMBL8774829 | 0.84 | RAB9A (0.36) | HSD17B10MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL8774180 | 0.82 | TAAR1 (0.47) | L3MBTL1HTTMAPTALDH1A1HPGD | |
| SCHEMBL9158863 | 0.82 | LMNA (0.46) | LMNAL3MBTL1HTTHSD17B10DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |