Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16069010 | 0.86 | ALDH1A1 (0.59) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL16061893 | 0.86 | ALDH1A1 (0.59) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL16061894 | 0.86 | ALDH1A1 (0.59) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1415895 | 0.84 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL8775648 | 0.84 | ALDH1A1 (0.56) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL8924844 | 0.83 | NPC1 (0.54) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL483306 | 0.82 | TGM2 (0.56) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL14855359 | 0.82 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL3928127 | 0.82 | LMNA (0.56) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL7448378 | 0.82 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312310-A1 | Compounds, Compositions and Methods | CYTOKINETICS, INC. | 2008-12-18 | — | — | US | claimed |
| EP-1554265-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2008-05-07 | — | — | EP | claimed |
| EP-1554265-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004024086-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2004-03-25 | — | — | WO | claimed |
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | claimed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | claimed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | claimed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0329013-A2 | Renin-inhibiting amino acid derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-23 | — | — | EP | claimed |
| EP-0047079-B1 | NONAPEPTIDES AFFECTING GONADAL FUNCTION | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1984-02-22 | — | — | EP | claimed |
| CN-112105385-A | IRAK degrading agents and uses thereof | 凯麦拉医疗公司 | 2020-12-18 | — | — | CN | disclosed |
| US-20140357654-A1 | METHODS OF TREATING SCHIZOPHRENIA WITH PHENYLALANINE ENAMIDE DERIVATIVE INHIBITORS OF a4 INTEGRIN POSSESSING A CYCLOBUTENE GROUP | AESTUS THERAPEUTICS, INC. (US) | 2014-12-04 | — | — | US | disclosed |
| EP-2775840-A1 | METHODS OF TREATING SCHIZOPHRENIA WITH PHENYLALANINE ENAMIDE DERIVATIVE INHIBITORS OF 4 INTEGRIN POSSESSING A CYCLOBUTENE GROUP | Aestus Therapeutics, Inc. (US) | 2014-09-17 | — | — | EP | disclosed |
| CN-103649076-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-19 | — | — | CN | disclosed |
| EP-0266978-A2 | Novel antibacterial agents and potentiators of carbapenem antibiotics | MERCK & CO. INC. (US) | 1988-05-11 | — | — | EP | disclosed |
| EP-0117448-B1 | PROCESS FOR THE PREPARATION OF N-ALKYLATED AMINO ACIDS AND THEIR ESTERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-09-03 | — | — | EP | disclosed |
| EP-0117448-A1 | Process for the preparation of N-alkylated amino acids and their esters | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-09-05 | — | — | EP | disclosed |
| US-4461761-A | IMMUNO-REGULATORS | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) | 1984-07-24 | — | — | US | disclosed |
| EP-0047079-B1 | NONAPEPTIDES AFFECTING GONADAL FUNCTION | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1984-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312310-A1 | Compounds, Compositions and Methods | ALPP, PCNA, MKI67 | ALDH1A1 2631/4885NPC1 170/4885RAB9A 2909/4885 |
| US-20140357654-A1 | METHODS OF TREATING SCHIZOPHRENIA WITH PHENYLALANINE ENAMIDE DERIVATIVE INHIBITORS OF a4 INTEGRIN POSSESSING A CYCLOBUTENE GROUP | ITGA4, ITGB4, EPB41 | ALDH1A1 522/4885NPC1 4589/4885RAB9A 3077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.