Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841463 | 0.88 | ADAM17 (0.37) | ADAM17RIPK1HSD17B2MMP13ADAM10 | |
| SCHEMBL839987 | 0.86 | ROCK2 (0.40) | ADAM17RIPK1HSD17B2L3MBTL1 | |
| SCHEMBL840338 | 0.85 | HRH3 (0.37) | ADAM17HRH3L3MBTL1 | |
| SCHEMBL840730 | 0.70 | OPRM1 (0.43) | — | |
| SCHEMBL9288414 | 0.69 | RIPK1 (0.40) | ADAM17RIPK1MMP13ADAM10MMP2 | |
| SCHEMBL840216 | 0.68 | TRPM8 (0.39) | ADAM17RIPK1 | |
| SCHEMBL9288755 | 0.68 | ROCK2 (0.43) | ADAM17RIPK1 | |
| SCHEMBL859592 | 0.68 | TRPM8 (0.39) | ADAM17RIPK1 | |
| SCHEMBL859295 | 0.66 | ROCK2 (0.41) | RIPK1 | |
| SCHEMBL1937979 | 0.64 | LMNA (0.43) | ADAM17RIPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324217-B2 | Cold menthol receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20120136006-A1 | COLD MENTHOL RECEPTOR ANTAGONISTS | COLBURN RAYMOND W (US) | 2012-05-31 | — | — | US | disclosed |
| US-8143259-B2 | Cold menthol receptor antagonists | JANSSEN PHARMACEUTICA, NV (BE) | 2012-03-27 | — | — | US | disclosed |
| US-20100048589-A1 | Cold Menthol Receptor Antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048589-A1 | Cold Menthol Receptor Antagonists | TRPV1, TRPM2, TRPM6 | ADAM17 4368/4885RIPK1 3006/4885HSD17B2 2470/4885 |
| US-20120136006-A1 | COLD MENTHOL RECEPTOR ANTAGONISTS | TRPV1, TRPM2, TRPM6 | ADAM17 4368/4885RIPK1 3006/4885HSD17B2 2470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.