Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798256 | 0.79 | TSHR (0.56) | ALDH1A1LMNAGAASMN1; SMN2MAPT | |
| SCHEMBL8799459 | 0.78 | PDK1 (0.55) | ALDH1A1LMNAGAASMN1; SMN2TRPV1 | |
| SCHEMBL27028620 | 0.77 | PDK1 (0.41) | ALDH1A1LMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL9035406 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL8800291 | 0.76 | ALDH1A1 (0.53) | ALDH1A1LMNAGAASMN1; SMN2PRSS1 | |
| SCHEMBL25252959 | 0.76 | HPSE (0.52) | ALDH1A1LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL31510258 | 0.75 | MAPK1 (0.56) | ALDH1A1LMNAGAASMN1; SMN2TRPV1 | |
| SCHEMBL4544584 | 0.75 | MAPK1 (0.56) | ALDH1A1LMNAGAASMN1; SMN2TRPV1 | |
| SCHEMBL8799443 | 0.74 | TBXAS1 (0.38) | ALDH1A1LMNATRPV1GRIN2DGRIN3B | |
| SCHEMBL7167920 | 0.73 | MAPT (0.44) | ALDH1A1LMNAHTTSMN1; SMN2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482771-B1 | Heterocyclic acids | ZENECA LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| US-5410064-A | Thromboxane A2 antagonists and inhibitors of thromboxane A2 synthase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-25 | — | — | US | disclosed |
| US-5219874-A | Heterocyclic acids | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| EP-0482771-A2 | Heterocyclic acids | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | disclosed |