Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799599 | 0.96 | FNTA (0.49) | HPGDHTTALDH1A1LMNANPSR1 | |
| SCHEMBL7811262 | 0.90 | FNTA (0.53) | HPGDHTTALDH1A1LMNANPSR1 | |
| SCHEMBL8799604 | 0.77 | FNTA (0.42) | HPGDHTTALDH1A1LMNANPSR1 | |
| SCHEMBL692174 | 0.75 | LMNA (0.49) | HTTALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL28673750 | 0.73 | ALDH1A1 (0.60) | HPGDHTTALDH1A1LMNANPSR1 | |
| SCHEMBL8798403 | 0.73 | PRKCZ (0.48) | HTTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL657182 | 0.73 | PRKCZ (0.48) | HTTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7812248 | 0.72 | MTNR1A (0.49) | HPGDHTT | |
| SCHEMBL12268167 | 0.71 | FNTA (0.47) | HTTALDH1A1LMNAGAASLC6A3 | |
| SCHEMBL9311962 | 0.70 | MEN1 (0.64) | HPGDHTTALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-A1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996039386-A1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |