SCHEMBL8799757

SCHEMBL8799757

Cc1nc(C)c(C(=O)NC(C#N)c2ccco2)s1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.51
RAB9A P51151 3/20 0.46
RECQL P46063 1/20 0.46
CTSV O60911 1/20 0.44
CTSL P07711 1/20 0.44
CTSB P07858 1/20 0.44
CTSS P25774 1/20 0.44
CTSK P43235 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 2/20 0.43
TP53 P04637 1/20 0.43
GAA P10253 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
TDP1 Q9NUW8 2/20 0.40
PKM P14618 1/20 0.40
ALDH1A1 P00352 4/20 0.39
HPGD P15428 1/20 0.39
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
NPSR1 Q6W5P4 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9528349 0.89 ALDH1A1 (0.51) LMNARAB9ASMN1; SMN2L3MBTL1TDP1
SCHEMBL8799762 0.86 MEN1 (0.39) LMNARAB9ACTSVCTSLCTSB
SCHEMBL9755465 0.83 HSD11B1 (0.36) LMNARAB9ASMN1; SMN2NPC1TP53
SCHEMBL8802116 0.80 RAB9A (0.42) LMNARAB9ARECQLCTSVCTSL
SCHEMBL8799895 0.79 RAB9A (0.46) LMNARAB9ARECQLCTSVCTSL
SCHEMBL9532579 0.77 RAB9A (0.37) RAB9ASMN1; SMN2NPC1L3MBTL1TDP1
SCHEMBL9533252 0.76 HTT (0.35) LMNARAB9ACTSLSMN1; SMN2NPC1
SCHEMBL8814094 0.76 RAB9A (0.43) LMNARAB9ARECQLCTSVCTSL
SCHEMBL9786414 0.75 LMNA (0.34) LMNARAB9ARECQLCTSLSMN1; SMN2
SCHEMBL10665838 0.75 CTSV (0.46) LMNARAB9ACTSVCTSLCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0517476-B1 Benzimidazole derivatives, a method for producing the same, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof SUMITOMO CHEMICAL CO (JP) 1997-10-08 EP claimed
EP-0517476-A2 Benzimidazole derivatives, a method for producing the same, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1992-12-09 EP claimed
JP-2286670-A None JP disclosed
EP-0517476-B1 Benzimidazole derivatives, a method for producing the same, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof SUMITOMO CHEMICAL CO (JP) 1997-10-08 EP disclosed
US-5472974-A Benzimidazole derivatives, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-12-05 US disclosed
US-5395952-A Nonphytotoxic SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-03-07 US disclosed
EP-0292937-B1 Amide derivatives, and their production and agricultural fungicides containing them SUMITOMO CHEMICAL CO (JP) 1994-08-10 EP disclosed
US-5310747-A Benzimidazole derivatives, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-05-10 US disclosed
EP-0313091-B1 AMIDE DERIVATIVES, PROCESSES FOR PRODUCTION THEREOF, AND AGRICULTURAL-HORTICULTURAL FUNGICIDE CONTAINING THEM MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-09-01 EP disclosed
EP-0517476-A2 Benzimidazole derivatives, a method for producing the same, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1992-12-09 EP disclosed
US-5104886-A Syntergistic mixtures of amide substituted thiazoles and other fungicides MITSUI TOATSU CHEMICALS, INC. (JP) 1992-04-14 US disclosed
US-4980363-A CONTROLLING PLANT DISEASES MITSUI TOATSU CHEMICALS, INC. (JP) 1990-12-25 US disclosed
JP-H02286670-A MINERAL ACID SALTS OF THIAZOLE CARBOXYLIC ACID CHLORIDE AND PRODUCTION THEREOF MITSUI TOATSU CHEM INC 1990-11-26 JP disclosed
US-4918089-A THIAZOLE DERIVATIVES; CURATIVE, NONPHYTOTOXIC SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1990-04-17 US disclosed
EP-0313091-A2 Amide derivatives, processes for production thereof, and agricultural-horticultural fungicide containing them MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-04-26 EP disclosed
EP-0292937-A1 Amide derivatives, and their production and agricultural fungicides containing them SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-11-30 EP disclosed