Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.67 |
| ▸ | HTR6 | P50406 | 6/20 | 0.62 |
| ▸ | HTR1D | P28221 | 5/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | HTR5A | P47898 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR1E | P28566 | 2/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444002 | 0.88 | MTNR1A (0.67) | MTNR1AMTNR1BHTR6HTR1DHTR1A | |
| SCHEMBL8691195 | 0.83 | HTR6 (0.71) | MTNR1AMTNR1BHTR6HTR1DTRPM8 | |
| SCHEMBL9304037 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1BTSHRCYP1A2KDM4E | |
| SCHEMBL8804026 | 0.80 | MTNR1A (0.59) | MTNR1AMTNR1BHTR6HTR1DTRPM8 | |
| SCHEMBL8947088 | 0.80 | HTR6 (0.73) | MTNR1AMTNR1BHTR6HTR1DTRPM8 | |
| SCHEMBL4244966 | 0.77 | HTR1D (1.00) | MTNR1AMTNR1BHTR6HTR1DTRPM8 | |
| SCHEMBL8229569 | 0.76 | HTR6 (0.72) | MTNR1AMTNR1BHTR6HTR1DTRPM8 | |
| SCHEMBL8946961 | 0.76 | HTR6 (0.72) | MTNR1AMTNR1BHTR6HTR1DTRPM8 | |
| Hydrochloric Acid SCHEMBL7433474 | 0.76 | HTR1D (0.97) | MTNR1AMTNR1BHTR6HTR1DTRPM8 | |
| SCHEMBL8805832 | 0.75 | MTNR1A (0.63) | MTNR1AMTNR1BADORA2BMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0754041-A4 | NOVEL SUBSTITUTED TRYPTAMINES, PHENALKYLAMINES AND RELATED COMPOUNDS | INTERNEURON PHARMA (US) | 1997-11-19 | — | — | EP | claimed |
| CN-1149252-A | Novel substituted tryptamines, phenylalkylamines and the like | INTERNEURON PHARMA (US) | 1997-05-07 | — | — | CN | claimed |
| EP-0754041-A1 | NOVEL SUBSTITUTED TRYPTAMINES, PHENALKYLAMINES AND RELATED COMPOUNDS | INTERNEURON PHARMACEUTICALS INCORPORATED (US) | 1997-01-22 | — | — | EP | claimed |
| WO-1995026723-A1 | NOVEL SUBSTITUTED TRYPTAMINES, PHENALKYLAMINES AND RELATED COMPOUNDS | INTERNEURON PHARMACEUTICALS, INC. (US) | 1995-10-12 | — | — | WO | claimed |
| EP-0754041-A4 | NOVEL SUBSTITUTED TRYPTAMINES, PHENALKYLAMINES AND RELATED COMPOUNDS | INTERNEURON PHARMA (US) | 1997-11-19 | — | — | EP | disclosed |
| CN-1149252-A | Novel substituted tryptamines, phenylalkylamines and the like | INTERNEURON PHARMA (US) | 1997-05-07 | — | — | CN | disclosed |
| EP-0754041-A1 | NOVEL SUBSTITUTED TRYPTAMINES, PHENALKYLAMINES AND RELATED COMPOUNDS | INTERNEURON PHARMACEUTICALS INCORPORATED (US) | 1997-01-22 | — | — | EP | disclosed |
| US-5580878-A | TREATING SLEEP DISORDERS | INTERNEURON PHARMACEUTICALS, INC. (US) | 1996-12-03 | — | — | US | disclosed |
| WO-1995026723-A1 | NOVEL SUBSTITUTED TRYPTAMINES, PHENALKYLAMINES AND RELATED COMPOUNDS | INTERNEURON PHARMACEUTICALS, INC. (US) | 1995-10-12 | — | — | WO | disclosed |
| US-5403851-A | Central nervous system and psychological disorders | INTERNEURON PHARMACEUTICALS, INC. (US) | 1995-04-04 | — | — | US | disclosed |
| US-5314908-A | Compounds useful as antiproliferative agents | WHITBY RESEARCH, INC. (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0549916-A2 | Compounds useful as antiproliferative agents | WHITBY RESEARCH, Inc. (US) | 1993-07-07 | — | — | EP | disclosed |
| US-5206377-A | Compounds useful as antiproliferative agents | WHITBY RESEARCH, INC. (US) | 1993-04-27 | — | — | US | disclosed |