Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.70 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807451 | 0.88 | ACHE (0.55) | OPRM1TMEM97SIGMAR1MCHR1ACHE | |
| SCHEMBL8789201 | 0.77 | ABCG2 (0.59) | OPRM1TMEM97SIGMAR1ABCB1ABCG2 | |
| SCHEMBL8807062 | 0.77 | OPRM1 (0.49) | OPRM1TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL8790765 | 0.76 | ABCG2 (0.56) | OPRM1TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL8808363 | 0.76 | MAOA (0.46) | OPRM1TMEM97SIGMAR1ACHEBCHE | |
| SCHEMBL8789467 | 0.75 | ABCG2 (0.49) | OPRM1TMEM97SIGMAR1ABCB1ABCG2 | |
| SCHEMBL8807941 | 0.75 | ABCB1 (0.57) | OPRM1TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL8809414 | 0.75 | ACHE (0.62) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL8806840 | 0.75 | ACHE (0.56) | OPRM1TMEM97SIGMAR1MCHR1ABCB1 | |
| SCHEMBL8790519 | 0.75 | ABCG2 (0.48) | OPRM1TMEM97SIGMAR1ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |