Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810439 | 0.93 | BCHE (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL8809141 | 0.77 | PARP1 (0.43) | MEN1KMT2AALDH1A1POLBKDM4E | |
| SCHEMBL15164064 | 0.74 | KDM4E (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8810148 | 0.74 | BCHE (0.42) | SMN1; SMN2ALDH1A1HTTL3MBTL1KDM4E | |
| SCHEMBL8810661 | 0.72 | TRIM24 (0.40) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL8808848 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTTP53ADORA2AMEN1 | |
| SCHEMBL8812096 | 0.68 | ALDH1A1 (0.40) | SMN1; SMN2MAPTTP53ADORA2AMEN1 | |
| SCHEMBL184150 | 0.68 | LMNA (0.61) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1038941 | 0.68 | LMNA (0.65) | MEN1KMT2AALDH1A1LMNAMAPK1 | |
| SCHEMBL8808211 | 0.66 | BCHE (0.42) | SMN1; SMN2MAPTALDH1A1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |