Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.39 |
| ▸ | SI | P14410 | 5/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.39 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8818927 | 0.88 | MGAM (0.41) | MGAMGAASIMGAM2PTGES | |
| SCHEMBL8818638 | 0.81 | PARP1 (0.45) | MGAMGAASIMGAM2PTGES | |
| SCHEMBL8816922 | 0.81 | ACHE (0.43) | MGAMGAASIMGAM2PRMT5 | |
| SCHEMBL8817000 | 0.80 | PRMT5 (0.34) | MGAMGAASIMGAM2PTGES | |
| SCHEMBL8816636 | 0.80 | ACHE (0.39) | MGAMGAASIMGAM2PRMT5 | |
| SCHEMBL8814868 | 0.79 | PRMT5 (0.32) | MGAMGAASIMGAM2PTGES | |
| SCHEMBL8814977 | 0.79 | ACHE (0.46) | MGAMGAASIMGAM2TRPV1 | |
| SCHEMBL8079568 | 0.77 | ACHE (0.46) | PRMT5DHODHLTA4H | |
| SCHEMBL8817544 | 0.73 | MGAM (0.50) | MGAMGAASIMGAM2RPS6KA3 | |
| SCHEMBL8818857 | 0.72 | PTGES (0.44) | MGAMGAASIMGAM2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997033873-A1 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | ELI LILLY AND COMPANY (US) | 1997-09-18 | — | — | WO | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |