Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424577 | 0.77 | TSHR (0.48) | MAOBMAOAANPEPTSHRKDM4E | |
| SCHEMBL28904739 | 0.76 | CA2 (0.37) | MAOBMAOAANPEPNPC1MAPT | |
| Methoxymethane SCHEMBL27610365 | 0.76 | KDM4E (0.42) | MAOBMAOANPC1MAPTRAB9A | |
| SCHEMBL1783171 | 0.73 | MAOB (0.43) | MAOBMAOAANPEPNPC1MAPT | |
| SCHEMBL7664111 | 0.73 | MAOB (0.43) | MAOBMAOAANPEPTSHRKDM4E | |
| SCHEMBL8496949 | 0.72 | MAOB (0.39) | MAOBMAOAANPEPTSHRKDM4E | |
| SCHEMBL8093208 | 0.72 | ALDH1A1 (0.48) | ANPEPMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL127705 | 0.72 | MAPT (0.52) | MAOBMAOANPC1MAPTRAB9A | |
| SCHEMBL20525259 | 0.71 | MAOA (0.38) | MAOBMAOAANPEPTSHRALDH1A1 | |
| SCHEMBL19746 | 0.70 | CYP19A1 (0.45) | MAOBMAOAANPEPMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656657-A | Chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-08-12 | — | — | US | disclosed |
| US-5656658-A | Method for the treatment of anxiety | ASTRA AKTIEBOLAG (SE) | 1997-08-12 | — | — | US | disclosed |
| US-5650524-A | Process for preparing (R)-3-amino-5-methoxychroman | ASTRA AKTIEBOLAG (SE) | 1997-07-22 | — | — | US | disclosed |
| US-5646309-A | Intermediates in the synthesis of chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-07-08 | — | — | US | disclosed |
| US-5641807-A | Method for the treatment of depression | ASTRA AKTIEBOLAG (SE) | 1997-06-24 | — | — | US | disclosed |
| US-5639772-A | Chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-06-17 | — | — | US | disclosed |
| US-5639784-A | ADMINISTERING 3-AMINO-5-CARBAMOYL-CHROMENES AND DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1997-06-17 | — | — | US | disclosed |
| US-5500425-A | Chroman derivatives and a method of treating 5-HT mediated disorders | AKTIEBOLAGET ASTRA (SE) | 1996-03-19 | — | — | US | disclosed |
| US-5420151-A | Chroman derivatives | AKTIEBOLAGET ASTRA (SE) | 1995-05-30 | — | — | US | disclosed |
| EP-0280269-B1 | 3-Amino-dihydro-[1]-benzopyrans and benzothiopyrans | CIBA-GEIGY AG (CH) | 1992-02-12 | — | — | EP | disclosed |