Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828558 | 0.80 | KAT2B (0.38) | NR3C1CXCR2 | |
| SCHEMBL8828501 | 0.78 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BKDM4EHSD17B10 | |
| SCHEMBL28454558 | 0.76 | ADRA1A (0.53) | ADRA1DADRA1AADRA1BKDM4EHSD17B10 | |
| SCHEMBL28455283 | 0.73 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BKDM4ESMN1; SMN2 | |
| SCHEMBL27614595 | 0.69 | HPGD (0.56) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13686035 | 0.69 | TERT (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL29212431 | 0.69 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BKDM4EHSD17B10 | |
| SCHEMBL8343253 | 0.67 | POLB (0.58) | ADRA1DADRA1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL21939459 | 0.67 | ALDH1A1 (0.41) | ADRA1DADRA1AADRA1BKDM4EHSD17B10 | |
| SCHEMBL11497416 | 0.65 | ALDH1A1 (0.59) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0711757-A1 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy -pyridine, pyrimidine and benzene derivatives as alpha1-adrenoceptor antagonists | F. Hoffmann-La Roche AG (CH) | 1996-05-15 | — | — | EP | disclosed |