SCHEMBL882953

SCHEMBL882953

NC(=O)c1cccc(NC(=O)OCc2ccccc2)c1

nearest known ligand 0.68

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 3/20 0.68
ENPP2 Q13822 3/20 0.61
RAB9A P51151 1/20 0.60
KDM1A O60341 1/20 0.59
MAOA P21397 1/20 0.59
KDM1B Q8NB78 1/20 0.59
RCOR1 Q9UKL0 1/20 0.59
PPIA P62937 1/20 0.57
POLB P06746 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6400257 0.89 MGLL (0.72) MGLLENPP2RAB9AKDM1AMAOA
SCHEMBL4057992 0.87 MGLL (0.70) MGLLENPP2RAB9AKDM1AMAOA
SCHEMBL15777029 0.84 TP53 (0.67) MGLLRAB9AKDM1AMAOARCOR1
SCHEMBL8490672 0.84 HPGD (0.64) MGLLRAB9A
SCHEMBL4066082 0.84 MGLL (0.65) MGLLENPP2RAB9AKDM1AMAOA
SCHEMBL13655148 0.84 MGLL (0.65) MGLLENPP2RAB9AKDM1AMAOA
SCHEMBL3583048 0.83 MGLL (0.72) MGLLENPP2RAB9APOLB
SCHEMBL8984657 0.82 MGLL (0.76) MGLLENPP2RAB9APOLB
Benzyl Phenylcarbamate SCHEMBL1222943 0.82 POLB (0.78) MGLLENPP2RAB9AKDM1AMAOA
SCHEMBL9560058 0.82 MGLL (0.62) MGLLENPP2RAB9AKDM1AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-11-02 US disclosed
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-11-02 US disclosed
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2023-06-13 US disclosed
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2023-06-13 US disclosed
EP-3888632-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS The Brigham and Women's Hospital, Inc. (US) 2021-10-06 EP disclosed
EP-3412279-B1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS BRIGHAM & WOMENS HOSPITAL INC (US) 2021-02-17 EP disclosed
US-20210008213-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS THE GENERAL HOSPITAL CORPORATION 2021-01-14 US disclosed
EP-2928457-B1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A ST EUROPEO DI ONCOLOGIA S R L (IT) 2020-08-12 EP disclosed
US-10675351-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2020-06-09 US disclosed
US-9974859-B2 Nanostructured gels capable of controlled release of entrapped agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2018-05-22 US disclosed
US-9974859-B2 Nanostructured gels capable of controlled release of entrapped agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2018-05-22 US disclosed
US-9944589-B2 Cycloproplyamine derivatives useful as inhibitors of histone demethylases KDM1A ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2018-04-17 US disclosed
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2017-01-05 US disclosed
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2017-01-05 US disclosed
US-20150315126-A1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2015-11-05 US disclosed
EP-2928457-A1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A Istituto Europeo di Oncologia S.r.l. (IT) 2015-10-14 EP disclosed
WO-2014086790-A1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2014-06-12 WO disclosed
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-10-24 US disclosed
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-10-24 US disclosed
WO-2012040623-A2 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2012-03-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210008213-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS MMP2, CEL, LIPA MGLL 95/4885ENPP2 2316/4885RAB9A 1945/4885
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MMP2, CEL, LIPA MGLL 95/4885ENPP2 2316/4885RAB9A 1945/4885
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MMP2, CEL, LIPA MGLL 95/4885ENPP2 2316/4885RAB9A 1945/4885
US-20150315126-A1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A KDM1A, KDM1B, KDM2A MGLL 4069/4885ENPP2 2632/4885RAB9A 3312/4885
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS MMP2, MMP1, GUSB MGLL 117/4885ENPP2 2068/4885RAB9A 2233/4885
US-10675351-B2 Nanostructured gels capable of controlled release of encapsulated agents MMP2, CEL, LIPA MGLL 95/4885ENPP2 2316/4885RAB9A 1945/4885
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents MMP2, CEL, LIPA MGLL 95/4885ENPP2 2316/4885RAB9A 1945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.