SCHEMBL8840197

SCHEMBL8840197

O=C(O)Cc1[c]cccc1-c1ccccc1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
HPGD P15428 3/20 0.42
THRA P10827 1/20 0.42
THRB P10828 1/20 0.42
FFAR4 Q5NUL3 1/20 0.42
SLC13A5 Q86YT5 1/20 0.40
AKR1C3 P42330 1/20 0.39
AKR1C2 P52895 1/20 0.39
KMO O15229 2/20 0.39
PTGS2 P35354 2/20 0.39
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
FFAR1 O14842 1/20 0.38
PPARG P37231 1/20 0.37
PPARA Q07869 1/20 0.37
POLQ O75417 1/20 0.37
LMNA P02545 2/20 0.36
POLB P06746 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21054410 0.78 PTGS1 (0.45) ALDH1A1HPGDHTTLMNAGAA
SCHEMBL9892644 0.76 PTGS2 (0.52) ALDH1A1HPGDTHRATHRBFFAR4
SCHEMBL7945398 0.72 CYP2C19 (0.41) ALDH1A1HPGDFFAR4LMNAKDM4E
SCHEMBL6987649 0.71 HSD11B1 (0.41) ALDH1A1HPGDTDP1
SCHEMBL12817256 0.71 HSD11B1 (0.41) ALDH1A1HPGDTDP1
SCHEMBL344491 0.71 ALDH1A1 (0.56) ALDH1A1HPGDAKR1C3AKR1C2KMO
SCHEMBL28757846 0.71 CXCL8 (0.41) ALDH1A1HPGDPTGS2HTTLMNA
SCHEMBL3416823 0.69 HSD11B1 (0.41) ALDH1A1HPGD
SCHEMBL1450954 0.69 AKR1B1 (0.50) ALDH1A1HPGDTHRBMAPTHTT
SCHEMBL197671 0.69 HSD11B1 (0.56) ALDH1A1HPGDPOLBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5641765-A TREATS PROSTATIC ADENOCARCINOMA, BENIGN PROSTATE HYPERTROPHY; ANTAGONSIT, ANTAGONISM SMITHKLINE BEECHAM CORPORATION (US) 1997-06-24 US disclosed
US-5618806-A STEROID 5ALPHA-REDUCTASE INHIBITOR; USEFUL FOR TREATING BENIGN PROSTATIC HYPERTROPHY, BALDNESS, ACNE, VULGURIS, SEBORRHEA, FEMALE HIRSUTISM, AND PROSTATIC ADENOCARCINOMA SMITHKLINE BEECHAM CORPORATION 1997-04-08 US disclosed
US-5527806-A 17α and 17β substituted acyl 4 aza steroids SMITHKLINE BEECHAM CORPORATION (US) 1996-06-18 US disclosed
WO-1995028413-A1 17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1995-10-26 WO disclosed
EP-0669932-A4 17-ALPHA AND 17-BETA SUBSTITUTED ACYL-3-CARBOXY-3,5-DIENES AND USE IN INHIBITING 5-ALPHA-REDUCTASE. SMITHKLINE BEECHAM CORP (US) 1995-10-25 EP disclosed
EP-0638090-A4 17-g(a) AND 17-g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID. SMITHKLINE BEECHAM CORP (US) 1995-10-04 EP disclosed
EP-0669932-A1 17-ALPHA AND 17-BETA SUBSTITUTED ACYL-3-CARBOXY-3,5-DIENES AND USE IN INHIBITING 5-ALPHA-REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1995-09-06 EP disclosed
EP-0641205-A4 17-g(a) AND 17-g(b) SUBSTITUTED ACYL 4 AZA STEROIDS. SMITHKLINE BEECHAM CORP (US) 1995-04-26 EP disclosed
EP-0641205-A1 17$g(a) AND 17$g(b) SUBSTITUTED ACYL 4 AZA STEROIDS SMITHKLINE BEECHAM CORPORATION (US) 1995-03-08 EP disclosed
EP-0638090-A1 17$g(a) AND 17$g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID SMITHKLINE BEECHAM CORPORATION (US) 1995-02-15 EP disclosed
WO-1994011386-A1 17-ALPHA AND 17-BETA SUBSTITUTED ACYL-3-CARBOXY-3,5-DIENES AND USE IN INHIBITING 5-ALPHA-REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1994-05-26 WO disclosed
WO-1993023042-A1 17α AND 17β SUBSTITUTED ACYL 4 AZA STEROIDS SMITHKLINE BEECHAM CORPORATION (US) 1993-11-25 WO disclosed
WO-1993022333-A1 17α AND 17β-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID SMITHKLINE BEECHAM CORPORATION (US) 1993-11-11 WO disclosed