Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030278 | 0.87 | TSHR (0.41) | TSHRFOLH1ALDH1A1TP53 | |
| SCHEMBL1741585 | 0.81 | TSHR (0.32) | TSHR | |
| SCHEMBL8841243 | 0.78 | GRIK1 (0.32) | TSHR | |
| SCHEMBL98864 | 0.78 | TSHR (0.46) | TSHRALDH1A1TP53 | |
| SCHEMBL6845389 | 0.78 | TSHR (0.36) | TSHRALDH1A1TP53 | |
| SCHEMBL11526385 | 0.76 | ALDH1A1 (0.42) | TSHRALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL7722330 | 0.76 | TSHR (0.44) | TSHRALDH1A1TP53 | |
| SCHEMBL10460142 | 0.76 | TSHR (0.50) | TSHRALDH1A1TP53 | |
| SCHEMBL9888612 | 0.76 | TSHR (0.34) | TSHRALDH1A1TP53 | |
| SCHEMBL27662647 | 0.75 | CA2 (0.48) | TSHRALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5160619-A | Crosslinked polyamide | NITTO DENKO CORPORATION (JP) | 1992-11-03 | — | — | US | claimed |
| US-10167287-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-09-14 | — | — | US | disclosed |
| US-9650384-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2017-05-16 | — | — | US | disclosed |
| US-9650384-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2017-05-16 | — | — | US | disclosed |
| WO-2016022881-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2016-02-11 | — | — | WO | disclosed |
| US-20160039830-A1 | Substituted Pyrimidine Compounds and Methods of Use and Manufacture | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2016-02-11 | — | — | US | disclosed |
| US-20160039830-A1 | Substituted Pyrimidine Compounds and Methods of Use and Manufacture | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2016-02-11 | — | — | US | disclosed |
| US-5616249-A | USING ALL ALIPHATIC POLYAMIDES FROM POLYAMINO COMPOUNDS AND COMPOUNDS HAVING TWO OR MORE ACID HALIDE GROUPS | IONICS, INCORPORATED (US) | 1997-04-01 | — | — | US | disclosed |
| US-5510527-A | Acid chloride | NITTO DENKO CORPORATION (JP) | 1996-04-23 | — | — | US | disclosed |
| US-5336409-A | Composite reverse osmosis membrane and novel acid chloride | NITTO DENKO CORPORATION (JP) | 1994-08-09 | — | — | US | disclosed |
| EP-0556569-A2 | Composite reverse osmosis membrane and novel acid chloride | NITTO DENKO CORPORATION (JP) | 1993-08-25 | — | — | EP | disclosed |
| US-5160619-A | Crosslinked polyamide | NITTO DENKO CORPORATION (JP) | 1992-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10167287-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DHFR, FOLR1, DPYD | TSHR 560/4885FOLH1 38/4885ALDH1A1 838/4885 |
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DHFR, FOLR1, DPYD | TSHR 560/4885FOLH1 38/4885ALDH1A1 838/4885 |
| US-20160039830-A1 | Substituted Pyrimidine Compounds and Methods of Use and Manufacture | DHFR, FOLR1, DPYD | TSHR 560/4885FOLH1 38/4885ALDH1A1 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.