Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 6/20 | 0.58 |
| ▸ | PGR | P06401 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8843481 | 0.82 | MMP3 (0.48) | TAS2R14KEAP1NFE2L2MTNR1BMAPT | |
| SCHEMBL8843594 | 0.77 | TAS2R14 (0.73) | TAS2R14PGRKEAP1NFE2L2CYP11B1 | |
| SCHEMBL13570528 | 0.75 | MMP9 (0.55) | KEAP1NFE2L2 | |
| SCHEMBL1279440 | 0.73 | TAS2R14 (1.00) | TAS2R14PGR | |
| SCHEMBL6773310 | 0.71 | BMP1 (0.56) | TAS2R14PGRKEAP1NFE2L2LMNA | |
| SCHEMBL20503326 | 0.69 | NPC1 (0.47) | SMN1; SMN2LMNA | |
| SCHEMBL6121647 | 0.69 | TAS2R14 (0.79) | TAS2R14PGR | |
| SCHEMBL8235218 | 0.69 | MMP2 (0.64) | TAS2R14PGR | |
| SCHEMBL1615513 | 0.68 | TAS2R14 (1.00) | TAS2R14 | |
| SCHEMBL29853546 | 0.68 | PGR (0.68) | TAS2R14PGRKEAP1NFE2L2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672615-A | MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS | NOVARTIS CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |