Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8857258 | 0.89 | KDM4E (0.40) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL8857701 | 0.89 | KMT2A (0.52) | KMT2AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL8484201 | 0.79 | SIGMAR1 (0.45) | KDM4EMAPT | |
| SCHEMBL8857440 | 0.75 | HPGD (0.43) | HPGDHTTMAPK1MAPTKMT2A | |
| SCHEMBL8975130 | 0.75 | FFAR1 (0.52) | PPARG | |
| SCHEMBL6032172 | 0.71 | MAPT (0.53) | KDM4EMAPTKMT2AALDH1A1CA2 | |
| SCHEMBL9782591 | 0.70 | ADRB2 (0.62) | HPGDHTTCA1CA2CA7 | |
| SCHEMBL22639802 | 0.70 | ADRB2 (0.62) | HPGDHTTCA1CA2CA7 | |
| SCHEMBL11067846 | 0.70 | ADRB2 (0.62) | HPGDHTTCA1CA2CA7 | |
| SCHEMBL8664520 | 0.69 | PPARG (0.56) | KDM4EMAPTPOLBPPARGCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688823-A | ANTILIPEMIC AGENTS, ANTIGLYCEMIC AGENTS, OBESITY, GLUCOSE TOLERANCE INSUFFICIENCY, INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1997-11-18 | — | — | US | disclosed |